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A study to Investigate whether a medication called Hyaluronidase, used to help Local Anesthesia work better, has any effect on eye pressure in patients undergoing Cataract Surgery.

Effect on intraocular pressure of inj hyaluronidase used as an adjuvant to local anaesthesia for peribulbar block in cataract - a prospective randomized double blinded comparative study. - NIL

Status
Active, not recruiting
Phases
Unknown
Study type
Interventional
Source
CTRI
Registry ID
CTRI/2025/04/084238
Enrollment
120
Registered
2025-04-07
Start date
Unknown
Completion date
Unknown
Last updated
2025-04-28

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: H00-H59- Diseases of the eye and adnexa

Interventions

Intervention1: Peribulbar block with LA with added inj hyaluronidase.: 60 patients in group 1 will receive peribulbar block with inj hyaluronidase added to local anaesthetic mixture of inj Lignocaine

Sponsors

Office of the Principal, Jalpaiguri Govt Medical College
Lead Sponsor

Eligibility

Inclusion criteria

Inclusion criteria: - ASA I,II,III patients - Normal IOP (10-20 mm Hg) - Normal baseline ECG - BP less than 160/90 mm Hg - CBG less than 200 mg/dl - Axial length of globe is 22-25 mm and in gonioscopy patient has open angle. - Cataract Operation under peribulbar block.

Exclusion criteria

Exclusion criteria: - hypersensitivity to hyaluronidase - hypersensitivity to any components of the injection. - pre existing ocular pathology, trauma or ocular movement restriction - pre existing glaucoma, high myopia or hypermetropia, eveitis - previous ocular surgery like vitrectomy, trabeculectomy - patient at increased risk for thrombosis - patient receiving salicylates, ACTH, cortisone, estrogen - patients with profound cognitive impairment, apprehension, requiring sedatives and analgesics, - unwillingness to participate in the study.

Design outcomes

Primary

MeasureTime frame
Intraocular pressure before and after peribulbar block with or without added inj hyaluronidase.Timepoint: Pre block and post block 1 min, 5 min,15 mins after block.

Secondary

MeasureTime frame
Vital parameters - HR, NIBP, SpO2Timepoint: Pre block and post block every 3 mins.;Block qualityTimepoint: 10 mins after block

Countries

India

Contacts

Public ContactDr Manisankar Nath

Jalpaiguri Govt Medical College and hospital

manisankarnath@gmail.com9434875617

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026