Health Condition 1: O- Medical and Surgical
Conditions
Interventions
Control Intervention1: Dexamethasone with ondansetran: Patient will receive Intravenous dexamethasone 0.1mg/kg & Intravenous ondansetron 4mg at the start of the surgery
Control Intervention2: Low Dose
Sponsors
Department of Anesthesiology
Eligibility
Inclusion criteria
Inclusion criteria: 1. ASA physical status I-II of either gender 2. Patient scheduled for laparoscopic cholecystectomy under general anesthesia 3. Non-smoker
Exclusion criteria
Exclusion criteria: 1. Pregnancy 2. Lactation 3. History of major surgery within the past 3 months 4. Inability to provide informed consent 5. H/O allergy or hypersensitivity to any study drugs 6. H/O pre-existing nausea or vomiting 7. H/O GI mobility disorders 8. H/O peptic ulcer disease 9. H/O use of anti-emetics, steroids, anti-histamines.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| To Compare the incidence of post operative nausea and vomiting,within the first 24 hours after surgery in patients receiving ondansetran with either low dose of methylprednisolone or dexamethasone.Timepoint: Vomiting Early 1st hour Vomiting Late 6th hour Vomiting Late 24th hour | — |
Secondary
| Measure | Time frame |
|---|---|
| 1. To assess the severity of PONV, including the number & intensity of nausea & vomiting episodes. 2. To evaluate the need for rescue antiemetics in each treatment group. 3. To compare the safety profile of low-dose methylprednisolone, dexamethasone, & ondansetron, including the incidence & severity of adverse effects.Timepoint: vomiting early 1st hour vomiting late 6th hour vomiting late 24th hour | — |
Countries
India
Contacts
Public ContactNilesh M
st Johns Medical College and hospital
Outcome results
None listed