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Chitosan Nanoparticles vs. EDTA: Which Irrigant Better Reduces Postoperative Pain?"

Comparative evaluation of chitosan nanoparticles and EDTA as intracanal irrigants in postoperative pain reduction - NIL

Status
Active, not recruiting
Phases
Phase 2Phase 3
Study type
Interventional
Source
CTRI
Registry ID
CTRI/2025/04/084082
Enrollment
40
Registered
2025-04-03
Start date
Unknown
Completion date
Unknown
Last updated
2025-04-28

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: K040- Pulpitis

Interventions

Intervention1: COMPARATIVE EVALUATION OF CHITOSAN NANOPARTICLES AND EDTA AS INTRACANAL IRRIGANTS IN POSTOPERATIVE PAIN REDUCTION : compare the post-operative pain levels in cases of symptomatic irreve

Sponsors

Government Dental College and hospital Ahmedabad
Lead Sponsor

Eligibility

Inclusion criteria

Inclusion criteria: 1) Posterior teeth diagnosed with symptomatic irreversible pulpitis without any periapical lesions 2)No previous root canal intervention

Exclusion criteria

Exclusion criteria: 10 Posterior teeth with periapical lesion more than 1 cm diameter patients with systemic conditions

Design outcomes

Primary

MeasureTime frame
The primary outcome of this study is the intensity of postoperative pain assessed at 6, 12, 24, 48 and 72 hours after root canal treatment using Numerical Rating Scale. Pain levels will be compared between the EDTA and chitosan nanoparticle irrigation groups to determine their effectiveness in postoperative pain reduction.Timepoint: 6, 12, 24, 48 and 72, 1 week

Secondary

MeasureTime frame
Incidence of Analgesic Intake: The number of patients requiring analgesics & the total dosage consumed within 48 hours postoperatively. Patient-Reported Outcomes: Subjective patient satisfaction regarding discomfort & overall treatment experience.Timepoint: 6, 12, 24, 48 & 72, 1 week

Countries

India

Contacts

Public ContactGeeta Asthana

Government Dental College and Hospital Ahmedabad

geetasthana@gmail.com9824440656

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026