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To see the effects of changing sevoflurane to desflurane for short duration before the end of general anaesthesia on awakening and recovery of patients.

A Randomised controlled study on the effects of switching from sevoflurane to short-term desflurane prior to the end of general anaesthesia on patient emergence and recovery - NIL

Status
Active, not recruiting
Phases
Unknown
Study type
Interventional
Source
CTRI
Registry ID
CTRI/2025/04/084022
Enrollment
50
Registered
2025-04-03
Start date
Unknown
Completion date
Unknown
Last updated
2025-04-28

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: R40-R46- Symptoms and signs involving cognition, perception, emotional state and behavior Health Condition 2: R00-R99- Symptoms, signs and abnormal clinical and laboratory findings, not elsewhere classified

Interventions

Intervention1: Switch from sevoflurane to short-term desflurane prior to the end of general anaesthesia: Studying the effects of switching from sevoflurane to short-term desflurane prior to end of gen

Sponsors

Department of Anaesthesiology and Critical Care, Jawaharlal Nehru Medical College and Hospital, AMU
Lead Sponsor

Eligibility

Inclusion criteria

Inclusion criteria: 1. Physical status of ASA I & II 2. Surgery expected to last for more than 2 hours under general anaesthesia

Exclusion criteria

Exclusion criteria: 1. Patients not giving consent 2. Pregnancy 3. Those with uncontrolled hypertension and cerebrovascular disease 4. Those with co-morbid diseases- cardiovascular, hepatorenal, pulmonary, haematological, neurological, metabolic, obesity (BMI- more than 30kg/m2) 5. Allergy to study drugs 6. Those with history of alcohol or drug abuse within 3 months of surgery 7. Patients having hearing impairment

Design outcomes

Primary

MeasureTime frame
To measure the recovery time which will be defined as the time to eye-opening from discontinuing the volatile anaesthetic on verbal command of the anaesthesiologistTimepoint: T1- Time of eye-opening from discontinuing the volatile anaesthetic agent—

Secondary

MeasureTime frame
1. To measure -the time to reach a BIS of 80 after discontinuing the anaesthetic agent -the time to return of spontaneous ventilation -the time to endotracheal extubation 2. To study haemodynamic changes in both the groups 3. To look for adverse effects of the anaesthetic agentTimepoint: 1. T80- Time to reach a BIS of 80 after discontinuing the anaesthetic agent 2. Tsv- Time to return of spontaneous ventilation 3. Te- Time to endotracheal extubation—

Countries

India

Contacts

Public ContactDr Rifa Tufail

Jawaharlal Nehru Medical College and Hospital, Aligarh Muslim University

obaidahmad2008@gmail.com9897695761

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026