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Benefit of thyroid supplementation on patients with asymptomatic hypothyroidism undergoing Coronary Bypass Grafting surgery

Impact of thyroid hormone supplementation on postoperative care in patients with subclinical hypothyroidism following on-pump coronary bypass grafting surgery- A randomized controlled trial - Nil

Status
Active, not recruiting
Phases
Unknown
Study type
Interventional
Source
CTRI
Registry ID
CTRI/2025/04/084008
Enrollment
300
Registered
2025-04-03
Start date
Unknown
Completion date
Unknown
Last updated
2025-04-28

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: I251- Atherosclerotic heart disease of native coronary artery Health Condition 2: E038- Other specified hypothyroidism

Interventions

Intervention1: Drug type: Given oral levothyroxine 25 mcg and oral liothyronine 5 mcg once Daily, orally , given till duration of study Control Intervention1: No hormone supplementation: Nil

Sponsors

AIIMS Jodhpur
Lead Sponsor

Eligibility

Inclusion criteria

Inclusion criteria: 1.All consenting patients 2.age of 18 to 80 years 3.undergoing elective on pump coronary bypass grafting surgery 4.TSH levels between 4.5 to 8mIU per mililitre

Exclusion criteria

Exclusion criteria: 1.Patients of age older than 80 years or younger than 18 years 2.Patients undergoing emergency surgery or re-do CABG operation 3.Patients undergoing concomitant valve surgery along with CABG in the same operation. oPatients with TSH levels greater than 8mIU/L

Design outcomes

Primary

MeasureTime frame
The primary outcome will be the comparison of ICU stay duration between the two groups (thyroid supplementation vs. no supplementation)Timepoint: Compared postoperatively, at end of 1 month postoperatively, 2 months postoperatively—

Secondary

MeasureTime frame
Secondary outcomes include the duration of mechanical ventilation, hospital stay, incidence of arrhythmias, need for IABP, and 30-day mortality.Timepoint: Postoperative day 0,1,2 and 30—

Countries

India

Contacts

Public ContactVikram Pal

AIIMS Jodhpur

sharmaak@aiimsjodhpur.edu.in9166553222

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026