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Is Ventilator assisted preoxygenation beneficial and effective in preoxygenation before intubation in hypoxemic patients when compared to standard bag and mask technique.

Comparison of VAPOX (Ventilator assisted preoxygenation) vs Standard preoxygenation in patients with acute hypoxemic respiratory failure: A open labelled randomized control trial.

Status
Active, not recruiting
Phases
Phase 4
Study type
Interventional
Source
CTRI
Registry ID
CTRI/2025/04/083946
Enrollment
74
Registered
2025-04-02
Start date
Unknown
Completion date
Unknown
Last updated
2025-04-28

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: J962- Acute and chronic respiratory failure

Interventions

Intervention1: Ventilator assisted preoxygenation(VAPOX): In Intervention group patient is optimally placed so that head is elevated with pad upto 20 ,ventilator assisted preoxygenation for 3 minutes

Sponsors

Christian Medical College Internal fluid research grant
Lead Sponsor

Eligibility

Inclusion criteria

Inclusion criteria: 1.Patients with acute hypoxemic respiratory failure with PaO2 less than 60 mm Hg,SpO2 less than 90%. 2.Patients with respiratory failure whose GCS less than 8 with inability to protect the airway and with hemodynamic compromise.

Exclusion criteria

Exclusion criteria: 1.Those not consenting for the study 2.Pregnancy 3.Suspected difficult airway due to reduced neck movements, mouth opening. 4.Recent facial, upper airway, or upper GI tract surgery

Design outcomes

Primary

MeasureTime frame
To estimate Lowest PaO2 recorded at 2 minutes after intubation.Timepoint: PaO2 recorded at 2 minutes after intubation by taking Arterial blood gas.

Secondary

MeasureTime frame
1. To find the Median drop in SpO2 during intubation. 2. To determine the percentage of adverse events during intubation. 3. To estimate the percentage of major cardiac events (cardiac arrest).Timepoint: Median drop in SpO2 seen during 0 minutes of intubation.

Countries

India

Contacts

Public ContactDr Priya G

Christian Medical College

priyajyotsnav@gmail.com8903308084

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026