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Role of Leptin gene in Diabetes

Analysis of Leptin Gene in Pathogenesis of Diabetes with relation to Clinical Phenotyping concept of Unani Philosophy. - NIL

Status
Active, not recruiting
Phases
Unknown
Study type
Observational
Source
CTRI
Registry ID
CTRI/2025/04/083914
Enrollment
200
Registered
2025-04-02
Start date
Unknown
Completion date
Unknown
Last updated
2025-04-28

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: E119- Type 2 diabetes mellitus without complications

Interventions

Intervention1: NIL: NIL Control Intervention1: NIL: NIL

Sponsors

Central Council for research in Unani Medicine Ministry of AYUSH Govt of India
Lead Sponsor

Eligibility

Inclusion criteria

Inclusion criteria: The patients diagnosed with Type II diabetes, and having a Fasting Blood Sugar of 126 175mg/ 100ml and Post Prandial Blood Sugar of 200-250mg/100ml and HbA1C above 6.5 - 8 and Subjects without diabetes for controls.

Exclusion criteria

Exclusion criteria: The Subjects who are unwilling to give the blood sample. Pregnant women, lactating women, cancer patients and mentally disorder people

Design outcomes

Primary

MeasureTime frame
Having a better understanding of the molecular mechanisms behind leptin and leptin receptors may enable researchers to address leptin dysregulation in type 2 diabetes more precisely and specifically related to glucose and insulin. Additionally, assessing the progression of the disease and early identification of high-risk individuals may benefit from examining the genetic markers implicated in leptin gene regulation at transcriptional levels. It would aid in the identification of possible treatment biomarkers and aid in comprehending their function in the pathophysiology of illness. To our knowledge, it would be the first association study of its sort examining the potential relationship between Unani temperament concept and T2DM with regard to LEP and LEPR genes. Ideally, it would act as a basis for encouraging further researchers to look into genetic indicators in conjunction with Unani philosophy.Timepoint: 3 years

Secondary

MeasureTime frame
the expected outcomes of this project aim to contribute to a holistic understanding of T2DM etiology, personalized medicine strategies, and the integration of traditional Unani philosophy with modern molecular research in healthcare.Timepoint: 3 years

Countries

India

Contacts

Public ContactTasleem Ahmad

National Research Institute of Unani Medicine for Skin Disorders (NRIUMSD)

tasleem786@rediffmail.com04023810246

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026