Health Condition 1: O- Medical and Surgical
Conditions
Interventions
Intervention1: Group D receive Inj. Dexmedetomidine 1.5 mcg/kg i.v.: Group D will receive Inj. Dexmedetomidine 1.5 mcg/kg i.v. diluted in 100ml Normal Saline over 20 minutes before induction of gener
Sponsors
Smt Bhikiben Kanjibhai Shah Medical Institute and Research Cen
Eligibility
Inclusion criteria
Inclusion criteria: Patients willing to sign written & informed consent. Male or female patients between ages of 18 to 60 years. Patients belonging to American Society of Anesthesiologists (ASA) physical status I and II. Patients posted for elective spine surgeries under general anesthesia
Exclusion criteria
Exclusion criteria: Patients unwilling to participate in the study. Patients with cardiovascular, cerebrovascular, hepatic and renal diseases. Patients having arrhythmias or heart block. Psychiatric patients. Pregnancy & lactating women. Patients taking beta blockers. History of allergy to the study drugs. Anticipated difficult airway. BMI greater than 30 Patient having Neuromuscular disease Serum magnesium level greater than 2.5mEq per L
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| This prospective and observational study will help us to compare the efficacy of intravenous Dexmedetomidine versus intravenous Magnesium sulphate for attenuation of the pressor response to larngoscopy and endotracheal intubation and will enable us to know which of the two drugs is most beneficial in providing better attenuation of the hemodynamic response to larngoscopy and endotracheal intubation.Timepoint: Monitoring of parameters i.e. HR, SBP, DBP, MAP, SPO2 will be noted at baseline, after administration of test drug, after induction, during laryngoscopy and intubation and at 1,3,5 minutes after intubation. | — |
Secondary
| Measure | Time frame |
|---|---|
| To study sedation score after extubation or any side effects.Timepoint: Ramsay sedation score (RSS) will be recorded at 1 minutes for 30 minutes 60 minutes and 90 minutes. | — |
Countries
India
Contacts
Public ContactDr Jatin Patel
Smt. Bhikiben Kanjibhai Shah Medical Institute and Research Centre
Outcome results
None listed