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how effective is hyaluronidase when used as an adjuvant to lignocaine when used as a local aneshtetic agent

Anesthetic Efficacy of Hyaluronidase as an Adjuvant to Lignocaine-Epinephrine in Maxillary Anterior Extractions: A Randomized Controlled Trial - NIL

Status
Active, not recruiting
Phases
Unknown
Study type
Interventional
Source
CTRI
Registry ID
CTRI/2025/04/083885
Enrollment
140
Registered
2025-04-02
Start date
Unknown
Completion date
Unknown
Last updated
2025-04-28

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: K002- Abnormalities of size and form ofteeth Health Condition 2: K029- Dental caries, unspecified Health Condition 3: K04- Diseases of pulp and periapical tissues Health Condition 4: K040- Pulpitis

Interventions

Intervention1: Anesthetic Efficacy of Hyaluronidase as an Adjuvant to Lignocaine-Epinephrine in Maxillary Anterior Extractions: A Randomized Controlled Trial: objective of this study is to assess the

Sponsors

DR ROSHANI R AUTADE
Lead Sponsor

Eligibility

Inclusion criteria

Inclusion criteria: patients requiring prophylactic or remedial extraction of maxillary central and lateral incisors

Exclusion criteria

Exclusion criteria: 2. Patient with co morbidities 3. History of immunosuppressant use within last 6 months 4. Past or ongoing chemotherapy or radiotherapy 5. Patients with altered hemodynamic values. 6. Women who are pregnant, lactating or taking oral contraceptives. 7. Allergy or hypersensitivity to any of the products used in the study. 8. Any pre operative infection or edema

Design outcomes

Primary

MeasureTime frame
pain, local anesthetic effect, time of onset of anesthesia, complicationsTimepoint: immediately after administration of local anesthetic, 30,60,90,120sec and so on.—

Secondary

MeasureTime frame
Time of onset of anesthesia after administration of Local Anesthetic solution, Other complication Localized / systemic Immediate /delayed Timepoint: Immediately after administration of anesthesia, after 30 seconds then at 60 seconds ,then 70,80,90,100,110,120 seconds.—

Countries

India

Contacts

Public ContactDr. Nishit K. Shah

Government Dental College and Hospital, Jamnagar, India 361008

drnishitomfs@gmail.com9324808625

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026