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This study will help in finding the pregnancy rate in a single ovulation induction cycle using a drug letrozole among PCOS women with or without prior drug induced bleed. Thereby finding out the extent to which the prior bleed affecting the ovulation rate,pregnancy rate and endometrial thickness.

Conception in single ovulation induction cycle using letrozole among PCOS women with and without prior withdrawal bleed A randomized controlled trial. - Nil

Status
Active, not recruiting
Phases
Unknown
Study type
Interventional
Source
CTRI
Registry ID
CTRI/2025/04/083878
Enrollment
120
Registered
2025-04-02
Start date
Unknown
Completion date
Unknown
Last updated
2025-04-28

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

None listed

Interventions

Intervention1: Anovulatory PCOS women undergoing ovulation induction using letrozole without prior MPA withdrawal bleed.: On the day of enrollment we start letrozole 5 mg OD for 5 days (assigned day 2

Sponsors

Jawaharlal Institute of Postgraduate Medical Education and Research
Lead Sponsor

Eligibility

Inclusion criteria

Inclusion criteria: Women diagnosed with PCOS by Rotterdam criteria and not resumed periods after 45 days or women who bleed only with MPA withdrawal Women between age 20 and 40 years Endometrial thickness of less than 7 mm All follicles in ovary should be measuring less than 10 mm

Exclusion criteria

Exclusion criteria: Women with functional ovarian cyst Known case of bilateral tubal block / hydrosalphinx Morbid obesity of BMI more than 40kg/m2 Severe male factor infertility

Design outcomes

Primary

MeasureTime frame
To compare the conception rate (Urine pregnancy test positive after ovulation induction) in a single ovulation induction cycle among anovulatory PCOS women using letrozole with and without prior MPA-induced withdrawal bleedTimepoint: conception rate—

Secondary

MeasureTime frame
To study ovulation rate & endometrial thickness in a single ovulation induction cycle among anovulatory PCOS women using letrozole with & without prior MPA-induced withdrawal bleedTimepoint: AT BASELINE(DAY 2 OF MENSES),DAY 11/12 OF MENSES,4 WEEKS AND 8 WEEKS—

Countries

India

Contacts

Public ContactDr Sujatha Venkatraman

Jawaharlal Institute of Postgraduate Medical Education and Research, pondicherry

drsujatharaman@gmail.com7598500890

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026