Health Condition 1: F20- Schizophrenia
Conditions
Interventions
Intervention1: H1 Deep Transcranial Magnetic Stimulation (dTMS), active: The helmet with H1 dTMS coil will be placed on the head of the patient. It will be adjusted such that, the maximal stimulation
Sponsors
Central Institute of Psychiatry
Eligibility
Inclusion criteria
Inclusion criteria: 1. Diagnosis of Schizophrenia using Clinical descriptions and diagnostic requirements for ICD-11 mental, behavioral and neurodevelopmental disorders (CDDR) (ICD-11 CDDR, World Health Organization, 2019). 2. Age between 10- 20 years of either sex. 3. Right-Handed 4. Onset of Illness before the age of 18 years. 5. The Positive and Negative Syndrome Scale for Schizophrenia (PANSS) negative symptoms score of more than 15. 6. Scale for Assessment of Negative Symptoms (SANS) score more than 20. 7. Calgary Depression Scale for Schizophrenia (CDSS) score less than 7. 8. Patients providing assent/consent and written informed consent provided by parents/caregivers for the study.
Exclusion criteria
Exclusion criteria: 1. Presence of co-morbid neurological or other psychiatric disorder(s). 2. Patients with co morbid substance dependence, except nicotine and caffeine. 3. Having any metallic implants/parts in body. 4. Subjects who have received ECT or any type of Neuromodulation in past 6 months.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Improvement in negative and cognitive symptoms of early onset schizophrenia as measured by PANSS, SANS, BACS, CGISCH after receiving adjuvant H1 dTMSTimepoint: Primary Outcomes are assessed at baseline, 2 and 6 weeks after intervention | — |
Secondary
| Measure | Time frame |
|---|---|
| Change in BOLD activity of Pre-Frontal Cortex, cortical plasticity, and resting state fMRI at baseline and after application of H1 dTMS.Timepoint: Secondary outcomes are assessed at baseline and at 2 weeks | — |
Countries
India
Contacts
Public ContactDr Nishant Goyal
Central Institute of Psychiatry
Outcome results
None listed