Health Condition 1: O141- Severe pre-eclampsia
Conditions
Interventions
Intervention1: compares the effectiveness of a loading dose alone versus the standard Pritchard regimen in preventing eclampsia among severe preeclampsia patients. Participants are randomized into two
Sponsors
Department of Obstetrics and Gynaecology
Eligibility
Inclusion criteria
Inclusion criteria: Patient giving written informed consent will be taken Any intrapartum pregnant women with severe preeclampsia according to the ACOG criteria Systolic blood pressure of 160 mm Hg or higher or diastolic blood pressure of 110 mm Hg or higher on Two occasions atheist 6 hours apart) Systolic blood pressure of 160 mm Hg or more, ordiastolic blood pressure of 110 mm Hg or moreon two occasions at least 4 hours apart (unlessantihypertensive therapy is initiated before thistime)Thrombocytopenia (platelet count than 100,000109L Impaired liver function that is not accounted forby alternative diagnoses and as indicated byabnormally elevated blood concentrations of liverenzymes (to more than twice the upper limitnormal concentrations), or by severe persistentright upper quadrant or epigastric pain unre-sponsive to medications Renal insufficiency (serum creatinine concentration more than 1.1 mg/dL or a doubling of theserum creatinine concentration in the absence ofother renal disease) Pulmonary edema New-onset headache unresponsive to medicationand not accounted for by alternative diagnoses Chronic Hypertension patients with superimposed Severe Pre eclampsia
Exclusion criteria
Exclusion criteria: Not giving consent Eclampsia patients (defined as presence of new onset grandmas seizures in woman with preeclampsia ) Severe Preeclampsia with known case of epilepsy Women with plasma creatinine value 2 mg dl (impared renal function Patients who are on intercurrent MgSO4 therapy Women those that were already on magnesium sulphate prophylaxis at admission
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| The primary outcome will be the occurrence of seizures in the mothersTimepoint: from admission till 72 hrs post delivery | — |
Secondary
| Measure | Time frame |
|---|---|
| secondary outcomes will be conversion to the standard regime due to persistence of signs & symptoms of impending eclampsia, signs of magnesium intoxication like postpartum hemorrhage Timepoint: till 1 week | — |
Countries
India
Contacts
Public ContactProf Pushpalata Sankhwar
King Georges Medical University Lucknow
Outcome results
None listed