Imaging to see the effect of surgery on outgoing fluid pathways of the eye in adults with glaucoma

Effect of GATT on Aqueous Humor Outflow channels and Schlemms canal in primary adult glaucoma: an Aqueous Angiography and ASOCT study - NIL

Status

Recruiting

Phases

Phase 2

Study type

Interventional

Source

CTRI

Registry ID

CTRI/2025/04/083846

Enrollment

Registered

2025-04-02

Start date

Unknown

Completion date

Unknown

Last updated

2025-10-13

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: H40- Glaucoma

Interventions

Intervention1: Gonioscopy-Assisted Transluminal Trabeculotomy (GATT): GATT (Gonioscopy-Assisted Transluminal Trabeculotomy) is a minimally invasive glaucoma surgery (MIGS), procedure used to treat gla

121(4):855 61 Control Intervention1: NOT APPLICABLE: Not applicable since there is no control group

Eligibility

Inclusion criteria

Inclusion criteria: Patients with Primary Glaucoma (POAG, JOAG, PACG) needing surgical intervention: 1 Uncontrolled on Maximum Topical Medication (MTM) 2 Progression on HVF despite MTM 3 Non compliant/allergic to MTM 4 Patients needing systemic AGMs for IOP control

Exclusion criteria

Exclusion criteria: 1) Patients with secondary causes of glaucoma (PDS, PEX, SIG, Trauma, Uveitis, NVG etc.) 2) Patients allergic to ICG dye 3) Patients with poor angle visualisation 4) Patients with any active ocular infection 5) History of previous ocular surgery 6) One eyed patients 7) Patients unwilling to give consent

Design outcomes

Primary

Measure	Time frame
To determine the changes in Aqueous Humor Outflow channels on ICGA and ASOCT post GATT in primary adult glaucoma patientsTimepoint: 6 months post surgery	—

Secondary

Measure	Time frame
To determine the reduction in IOP post GATT in primary adult glaucoma patientsTimepoint: 1 month, 3 months and 6 months post surgery;To determine the reduction in number of anti glaucoma medications post GATT in primary adult glaucoma patientsTimepoint: 1 month, 3 months and 6 months post surgery;To determine the improvement in best corrected visual acuity (BCVA) post GATT in primary adult glaucoma patientsTimepoint: 1 month, 3 months and 6 months post surgery;To determine the safety outcomes of GATT in primary adult glaucoma patients in terms of eyes developing complications post surgeryTimepoint: Post operative day, 1 month, 3 months and 6 months post surgery	—

Measure

Time frame

To determine the reduction in IOP post GATT in primary adult glaucoma patientsTimepoint: 1 month, 3 months and 6 months post surgery;To determine the reduction in number of anti glaucoma medications post GATT in primary adult glaucoma patientsTimepoint: 1 month, 3 months and 6 months post surgery;To determine the improvement in best corrected visual acuity (BCVA) post GATT in primary adult glaucoma patientsTimepoint: 1 month, 3 months and 6 months post surgery;To determine the safety outcomes of GATT in primary adult glaucoma patients in terms of eyes developing complications post surgeryTimepoint: Post operative day, 1 month, 3 months and 6 months post surgery

—

Countries

India

Contacts

Public ContactDr Shikha Gupta

All India Institute of Medical Sciences, New Delhi

dr.shikhagupta84@gmail.com9910015999

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026