To study Effectiveness of preinduction ketamine versus magnesium sulphate nebulization on the incidence of sore throat after general endotracheal anesthesia.

Effectiveness of preinduction ketamine versus magnesium sulphate nebulization on the incidence of sore throat after general endotracheal anesthesia: A prospective randomized double blind comparative study. - NIL

Status

Active, not recruiting

Phases

Phase 4

Study type

Interventional

Source

CTRI

Registry ID

CTRI/2025/04/083842

Enrollment

Registered

2025-04-02

Start date

Unknown

Completion date

Unknown

Last updated

2025-04-28

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: - Health Condition 2: O- Medical and Surgical

Interventions

Intervention1: Group Ketamine (Group K): After thorough pre anesthetic evaluation, all study participants will be received tablet alprazolam 0.25 mg night before surgery and tablet pantop 40 mg mornin

Eligibility

Inclusion criteria

Inclusion criteria: 1)Patients aged 18 to 65 years. 2)Patients with American Society of Anesthesiologists (ASA) physical status I to III 3)Patients with Mallampati grade (MPG) I to III 4)Patients scheduled to undergo elective surgery of 4 hours duration who requires general endotracheal anesthesia.

Exclusion criteria

Exclusion criteria: 1)Patients having history of preoperative sore throat or recent upper respiratory tract infection. 2)Patients undergoing oral surgeries, neck surgeries like thyroid surgery. 3)Patients with known allergy to study drug. 4)Hypertensive patients. 5)Patients with raised renal parameters. 6)Patients requiring more than 3 attempts at intubation. 7)Pregnant and lactating women. 8)Patients not willing to give consent.

Design outcomes

Primary

Measure	Time frame
To compare efficacy of ketamine nebulization versus magnesium sulphate nebulization on incidence post operative sore throatTimepoint: at induction, 2 hours, 4 hours, 6 hours and 12 hours	—

Secondary

Measure	Time frame
1.Incidence of postoperative cough and hoarseness of voice 2.Severity of postoperative sorethroat 3.Severity of postoperative cough 4.Severity of postoperative hoarseness 5.Risk of adverse effects due to study drugsTimepoint: at 0,1,2,4,6 and 24 hours after tracheal extubation	—

Countries

India

Contacts

Public ContactDr M Madhusudan

Sri venkateswara institute of medical sciences(SVIMS)

drmadhu37@gmail.com9493547723

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026