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Effects of Pregabalin on Anxiety, Sleep, and Heart Stability in Patients Undergoing Heart Bypass Surgery Without a Heart-Lung Machine

A PROSPECTIVE COMPARATIVE STUDY ON THE EFFECTS OF ORAL PREGABALIN ON ANXIETY, SLEEP QUALITY, AND HEMODYNAMIC STABILITY IN PATIENTS UNDERGOING OFF-PUMP CORONARY ARTERY BYPASS GRAFTING (OPCAB): A COMPARISON BETWEEN PREGABALIN AND CONTROL GROUP - NIL

Status
Active, not recruiting
Phases
Unknown
Study type
Interventional
Source
CTRI
Registry ID
CTRI/2025/04/083833
Enrollment
92
Registered
2025-04-01
Start date
Unknown
Completion date
Unknown
Last updated
2025-04-28

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: O- Medical and Surgical

Interventions

Intervention1: pregabalin: preoperative drug is administered using standard drugs with 75 mg of pregabalin drug to observe the anxiety sleep quality and hemodynamics instability. Control Intervention1

Sponsors

SRM Medical College and Hospital
Lead Sponsor

Eligibility

Inclusion criteria

Inclusion criteria: 1.ASA physical status I III 2.Off-pump CABG procedures

Exclusion criteria

Exclusion criteria: 1.Patient refusal 2.Non-sternotomy Cardiac procedures 3.Allergy to Pregabalin drugs 4.Emergency surgeries 5.Patients who taking anticonvulsants, antidepressant drugs

Design outcomes

Primary

MeasureTime frame
To evaluate the effect of preoperative oral pregabalin on reducing anxiety levels using, the VAS, State-Trait Anxiety Inventory scale as compared to control group. Timepoint: Assessment will include before 30 mins drug administration and after 30 mins, 12 hours of drug administartion—

Secondary

MeasureTime frame
To determine the impact of preoperative oral pregabalin on improving sleep quality, using the SATED Scale and stabilizing hemodynamic parameters as compared to control group. Timepoint: Assessment will include before 30 mins drug administration and after 30 mins, 12 hours of drug administartion—

Countries

India

Contacts

Public ContactGokulnath V

SRM medical college and hospital SRM Nagar Potheri

vgokulnathnemili@gmail.com6382066287

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026