Health Condition 1: G248- Other dystonia
Conditions
Interventions
Intervention1: SPECT aided botulinum toxin injection: The intervention group patients will also receive botulinum toxin injection via EMG Guidance, but here the muscle selection is based on SPECT MBR
Sponsors
AIIMS Delhi
Eligibility
Inclusion criteria
Inclusion criteria: 1. Patients with writers cramp, fulfilling the definition of focal hand dystonia as per MDS (and confirmed by 2 movement disorder specialists) 2. Use of stable doses of anti-dystonic drugs for the last one month 3. Patients aged more than 18 years 4. Patients who have not received Botulinum toxin injection, or have last received it at least more than 4 months age
Exclusion criteria
Exclusion criteria: 1. Patients who have underwent surgical treatment for focal dystonia (Pallidotomy) 2. Clinical evidence of Parkinsonism or cerebellar ataxia 3. Pregnancy 4. Contra-indications to botulinum toxin like anterior horn cell disease or neuro- muscular junction disorders
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Difference in WCRS and UDRS scores at 3 weeks between the study and the control groups and hence the efficacy of SPECT aided botulinum toxin injection as compared to clinical examination-based injectionTimepoint: 3 weeks | — |
Secondary
| Measure | Time frame |
|---|---|
| 1. Subjective improvement between the two groups at 3 weeks and 12 weeks (PGIC scale and Likert s scale) and their comparison 2. Adverse effect profile of SPECT aided botulinum toxin injection at 3 weeks and 12 weeks (Grip strength by handheld dynamometer and self- reported adverse events) and comparison of the same with the control group 3. Handwriting kinematics - mainly improvement in the writing speed at the end of 3 weeks in both the groupsTimepoint: 3 weeks and 12 weeks | — |
Countries
India
Contacts
Public ContactDr Thrupthi KM
AIIMS Delhi
Outcome results
None listed