Health Condition 1: I259- Chronic ischemic heart disease, unspecified Health Condition 2: I359- Nonrheumatic aortic valve disorder, unspecified Health Condition 3: I349- Nonrheumatic mitral valve disorder, unspecified Health Condition 4: I52- Other heart disorders in diseasesclassified elsewhere Health Condition 5: I069- Rheumatic aortic valve disease, unspecified Health Condition 6: I059- Rheumatic mitral valve disease, unspecified
Conditions
Interventions
Intervention1: PROPOFOL group: Patients will be induced with propofol bolus (1.5-2 mg/kg) followed by maintenance of anesthesia with propofol infusion at 50-150 mcg/kg/min during the intraoperative pe
Sponsors
Sree Chitra Tirunal Institute for Medical Sciences and Technology Thiruvananthapuram
Eligibility
Inclusion criteria
Inclusion criteria: 1. Patients undergoing cardiac surgeries such as coronary artery bypass surgery-on and off CPB, valvular repair or replacement and aortic surgeries.
Exclusion criteria
Exclusion criteria: 1. Acute or chronic liver disease 2. Acute or chronic kidney disease 3. History of neurological illness 4. Any known allergy to anesthetic components 5. Poor temporal window for MCA insonation 6. Poor insonation window for ONSD 7. Hemodynamically significant stenosis of carotid artery 8. Patients on medications like anticholinergic antidepressants, antiepileptics, anti-parkinson drugs 9. Severe left ventricular dysfunction 10. Redo and emergency surgeries 11. Patient remains intubated for more than 2 postoperative days with complicated postoperative course 12. Patient undergoing re-exploration following the primary surgery 13. Mortality following the primary surgery due to complicated postoperative course 14. Poor language comprehension 15. Patient refusal to consent
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| 1.Comparison of effect of sevoflurane and propofol on perioperative MCA Doppler flow velocities by TCCD in patients undergoing cardiac surgery. 2.Comparison of effect of sevoflurane and propofol on perioperative ONSD in patients undergoing cardiac surgery. Timepoint: pre induction, post induction, pre CPB, on CPB, post CPB, post operatively at 6 hours and 24 hours. | — |
Secondary
| Measure | Time frame |
|---|---|
| 1. Correlation between ONSD and MCA Doppler flow velocities at different time points of the perioperative period. 2. Analyse the incidence of early POCD between the two groups. 3. Correlation between ONSD, MFV in MCA, PI, ICP and CPP with the incidence of POCD. 4. Postoperative ICU requirement of sedatives or antipsychotics between the two groups. 5. Duration of mechanical ventilation, length of ICU stay and length of hospital stay between the two groups. Timepoint: TCCD and ONSD at pre induction, post induction, pre CPB, on CPB, post CPB, post operatively at 6 hours and 24 hours. Neurocognitive assessment preoperatively, postoperative day 1,2,7. | — |
Countries
India
Contacts
Public ContactDr Suneel PR
Sree Chitra Tirunal Institute for Medical Sciences and Technology
Outcome results
None listed