Comparing injection of Dexmedetomidine and Lidocaine for Pain Relief in Women Undergoing Laparoscopic Surgery

Comparison of Intravenous Dexmedetomidine and Lidocaine infusion for Perioperative Analgesic Consumption in Patient s Undergoing Laparoscopic Gynaecological Surgeries: A Randomized Study - NIL

Status

Active, not recruiting

Phases

Phase 4

Study type

Interventional

Source

CTRI

Registry ID

CTRI/2025/04/083772

Enrollment

Registered

2025-04-01

Start date

Unknown

Completion date

Unknown

Last updated

2026-09-14

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: O- Medical and Surgical

Interventions

Intervention1: d: d Intervention2: Group D: Intravenous infusion Dexmedetomidine 1mcg/kg over 10 minutes before anaesthesia induction followed by 0.3 mcg/kg/hour after anaesthesia induction.: On the d

Eligibility

Inclusion criteria

Inclusion criteria: ASA class I and II , scheduled For Elective Laparoscopic Gynecological surgeries like Hysterectomy, Adnexectomy, Myoma enucleation, Diagnostic laparoscopy etc

Exclusion criteria

Exclusion criteria: Non consenting patient, Malignant surgeries, BMI More Than 30 Kilogram Per Metre Square, Pregnant and Breastfeeding patients, history of chronic pain on analgesics and sedatives, significant or major comorbidities such as congestive heart failure, myocardial infarction in the past 6 months, heart block, fixed cardiac output lesions, chronic liver or kidney illnesses, and chronic use of opioids or opioid addiction, steroids, allergy to any medication, previous treatment with anti-platelet agents, antihypertensive medication with clonidine or other beta 2 adrenergic agonist, and inability to comprehend postoperatively the pain assessment scale and sedation scale.

Design outcomes

Primary

Measure	Time frame
1.To compare the duration of post operative analgesia(defined as the time to first request for rescue analgesia following extubation, when VAS is more than four between the group receiving Dexmedetomidine 1 mcg/kg over 10 min before anesthesia induction followed by infusion at 0.3 mcg/kg/min after anesthesia induction and the group receiving 2% Lidocaine hydrochloride 1.5 mg/kg over 10 min before anesthesia induction followed by infusion at 1.5mg/kg/h after anesthesia induction 2.To evaluate the cumulative postoperative rescue analgesic consumption within the first 24 hours, after extubation.Timepoint: At Extubation 15 min 30 min 1 hr 2 hr 3 hr 4 hr 8 hr 12hr 24h	—

Measure

Time frame

1.To compare the duration of post operative analgesia(defined as the time to first request for rescue analgesia following extubation, when VAS is more than four between the group receiving Dexmedetomidine 1 mcg/kg over 10 min before anesthesia induction followed by infusion at 0.3 mcg/kg/min after anesthesia induction and the group receiving 2% Lidocaine hydrochloride 1.5 mg/kg over 10 min before anesthesia induction followed by infusion at 1.5mg/kg/h after anesthesia induction 2.To evaluate the cumulative postoperative rescue analgesic consumption within the first 24 hours, after extubation.Timepoint: At Extubation 15 min 30 min 1 hr 2 hr 3 hr 4 hr 8 hr 12hr 24h

—

Secondary

Measure	Time frame
1.Total intraoperative Inj. Fentanyl consumption in both the groups. 2.VAS scores measured at predefined intervals 3.Sedation levels measured using the Ramsay Sedation Score at predefined intervals 4.Intraoperative Hemodynamic instability requiring interventions for bradycardia, hypotension and frequency of post operative side effects like PONV, shivering, bowel functionTimepoint: 15min 30 min 1 hr 2 hr 3 hr 4 hr 8 hr 12 hr, 24 hr post-extubation	—

Measure

Time frame

1.Total intraoperative Inj. Fentanyl consumption in both the groups. 2.VAS scores measured at predefined intervals 3.Sedation levels measured using the Ramsay Sedation Score at predefined intervals 4.Intraoperative Hemodynamic instability requiring interventions for bradycardia, hypotension and frequency of post operative side effects like PONV, shivering, bowel functionTimepoint: 15min 30 min 1 hr 2 hr 3 hr 4 hr 8 hr 12 hr, 24 hr post-extubation

—

Countries

India

Contacts

Public ContactDr Pranita Mandal

All India Institute Of Medical Sciences, Bhopal

pranita.anesth@aiimsbhopal.edu.in8800768428

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Sep 19, 2026