Health Condition 1: A419- Sepsis, unspecified organism
Conditions
Interventions
Intervention1: meropenem dose adjustment: patients in Group 2 will receive the standard meropenem 2g every 8 hours for 48 hours, with dose adjustment made only after 48 hours based on their creatinine
Sponsors
Amrita school of pharmacyAmrita viswa vidhyapeedam
Eligibility
Inclusion criteria
Inclusion criteria: All adult inpatients prescribed with Meropenem for sepsis with acute kidney injury with no known chronic kidney disease and documented renal impairment based on creatinine clearance values Patients who are treated with a standard dose of meropenem 2g every 8 hours (prolonged infusion over 3 hours) Patients who are willing to provide informed consent.
Exclusion criteria
Exclusion criteria: Outpatients antibiotic therapy Patients below 18 years of age Pregnant and lactating women Patients with chronic kidney disease
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| clinical outcomes associated with meropenem therapy All-cause mortality at 28thday length of hospital stay vasopressor-free days ventilator-free days in sub cohort of patients with early renal dose modification and late renal dose modificationTimepoint: 3 weeks | — |
Secondary
| Measure | Time frame |
|---|---|
| changes in renal function parameters (serum creatinine & GFR), need for renal replacement therapy & their impact on meropenem dosing adjustments Timepoint: 2 week | — |
Countries
India
Contacts
Public ContactAngel rose Varghese
Amrita institute of medical sciences
Outcome results
None listed