Health Condition 1: K85- Acute pancreatitis
Conditions
Interventions
Intervention1: Piperacillin-tazobactum: Dose: 4.5 g.
Frequency: every 8th hourly.
Route of administration: Intravenous
Duration: based on procalcitonin (PCT).
Algorithm for administration:
PCT wil
Sponsors
AIIMS Mangalagiri
Eligibility
Inclusion criteria
Inclusion criteria: 2. Valid informed consent 3. A diagnosis of acute pancreatitis requiring two of the following three features (as per revised Atlanta classification and definitions of acute pancreatitis, 2012) a. abdominal pain consistent with acute pancreatitis (acute onset of a persistent, severe, epigastric pain often radiating to the back) b. serum lipase activity (or amylase activity) at least three times greater than the upper limit of normal c. Characteristic findings of acute pancreatitis on contrast-enhanced computed tomography (CECT), magnetic resonance imaging (MR) or transabdominal ultrasonography (interstitial oedematous pancreatitis and necrotising pancreatitis
Exclusion criteria
Exclusion criteria: 1. Patients on immunosuppressive therapy 2. Immunocompromised patients (eg HIV, severe neutropenia) 3. Pre-existing organ dysfunctions (CKD, CHF, CVA with neurological deficits, CLD) 4. Acute pancreatis treated in outside facility with antibiotic usage more than 48 hours and referred cases
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Duration of antibiotic usageTimepoint: 7 days | — |
Secondary
| Measure | Time frame |
|---|---|
| ICU length of stay Hospital length of stay Timepoint: 28 days, 90 days;Infection of pancreatic necrosis - defined either as a result of fine needle aspiration (FNA), radiological evidence of gas in a peri-pancreatic collection or positive microbiological cultures from surgical or post-mortem specimensTimepoint: 28 days, 90 days;d. Incidence of multi-resistant bacteria/microbes (clinical isolates resistant to 2 antibiotics as per sensitivity profile)Timepoint: 28 days, 90 days;Use of radiological, endoscopic or surgical interventionTimepoint: 28 days, 90 days;Re-admission to hospitalTimepoint: 28 days, 90 days;Survival - time-to-event (mortality) survival (Kaplan Maier)Timepoint: 90-days;Case fatality rateTimepoint: 28 days;Organ DysfunctionTimepoint: 28 days, 90 days | — |
Countries
India
Contacts
Public ContactDr Mallikarjun Gunjiganvi
AIIMS Mangalagiri
Outcome results
None listed