A study comparing the effect of a local anesthetic alone versus a combination of a local anesthetic and a steroid in reducing pain and swelling after wisdom tooth removal.

Comparative Evaluation of Clinical Efficacy of Lignocaine Hydrochloride vs Lignocaine Hydrochloride with Dexamethasone in Reducing Discomfort Following Mandibular Third Molar Extractions: A Randomized, Controlled, Split-Mouth Study - NIL

Status

Active, not recruiting

Phases

Phase 4

Study type

Interventional

Source

CTRI

Registry ID

CTRI/2025/03/083691

Enrollment

Registered

2025-03-28

Start date

Unknown

Completion date

Unknown

Last updated

2025-04-07

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: O- Medical and Surgical

Interventions

Intervention1: Lidocaine Hydrochloride + Dexamethasone: A solution of 2% lidocaine hydrochloride with 1:200,000 epinephrine combined with dexamethasone (4 mg) administered as an inferior alveolar nerv

Eligibility

Inclusion criteria

Inclusion criteria: Patients requiring bilateral impacted mandibular third molar extractions. ASA I or ASA II patients No known allergies to local anesthetics or dexamethasone. Willing to participate and provide informed consent.

Exclusion criteria

Exclusion criteria: Patients with systemic conditions affecting wound healing (e.g., diabetes, immunosuppression). Pregnant or lactating women (if applicable). Known allergy to lignocaine or dexamethasone. Active infections at the surgical site. Use of anti-inflammatory or steroid medications within a certain period before surgery.

Design outcomes

Primary

Measure	Time frame
Swelling, mouth opening, PainTimepoint: Immediate postoperative, Day 1 , Day 3 , Day 5, and Day 7	—

Secondary

Measure	Time frame
pain on injection, onset and duration of anesthesiaTimepoint: immediate post operative	—

Countries

India

Contacts

Public ContactDr Rishabh Pahwa

Sudha Rustagi College of Dental Sciences and Research

drashish71@gmail.com

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026