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To study the effect of collagen crosslinking (bonding) using variable energy levels in progressive keratoconus (weak cornea) with thin cornea

To study the clinical & biomechanical outcomes of collagen crosslinking using adjusted fluency in progressive keratoconus with thin cornea - NIL

Status
Active, not recruiting
Phases
Unknown
Study type
Interventional
Source
CTRI
Registry ID
CTRI/2025/03/083481
Enrollment
30
Registered
2025-03-26
Start date
Unknown
Completion date
Unknown
Last updated
2025-04-07

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: H186- Keratoconus

Interventions

Intervention1: Corneal collagen cross linking of eye: Eligible patients (progressive keratoconus) will undergo collagen cross linking procedure with hypotonic riboflavin solution & UV-B with adjusted

Sponsors

Sankara Eye Hospital
Lead Sponsor

Eligibility

Inclusion criteria

Inclusion criteria: Keratoconus Patient from Age 10 to 30yrs Primary Keratoconus Thin corneas (Corneal pachymetry at thinnest point less than 400 microns)

Exclusion criteria

Exclusion criteria: Not willing for C3R surgery Endothelial disorder Prior herpetic infection/Concurrent infection/Inflammation Pre-existing ocular trauma Severe corneal scarring or opacification Pregnant and nursing mother Previous intraocular and corneal surgery Glaucoma Hormonal Therapy

Design outcomes

Primary

MeasureTime frame
To compare clinical outcomes using adjusted fluency vs standard hypo-osmolar Collagen Crosslinking in Progressive Keratoconus Ectasia stabilization by 1. Serial Tomography evaluation 2.Serial Corneal Biomechanical Profile evaluation using Corvis ST Timepoint: Preop (baseline), Post op Day 5, Post op 1 Month,Post op 3 Month, Post op 6 Month, Post op 12 Month—

Secondary

MeasureTime frame
1. Endothelial Status using Specular Microscopy 2. Higher Order Aberration using Tomography 3. Demarcation Line using ASOCT 4. Determine Quality of Life(QOL) Improvement using Indian Visual questionnaires Timepoint: Preop (baseline), Post op Day 5, Post op 1 Month,Post op 3 Month, Post op 6 Month, Post op 12 Month—

Countries

India

Contacts

Public ContactDr. Pallavi Joshi
drpallavijoshi@gmail.com8147280162

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026