Health Condition 1: S062- Diffuse traumatic brain injury Health Condition 2: G998- Other specified disorders of nervous system in diseases classified elsewhere
Conditions
Interventions
Intervention1: Transcranial Direct Current Stimulation: The patient will be positioned in supine lying, with tCDS will be applied first to the left dorsolateral prefrontal cortex (lDLPFC)or to the bil
Sponsors
Ravi Nair Physiotherapy College
Eligibility
Inclusion criteria
Inclusion criteria: Male or Female Participants in coma following TBI with GCS scores less than or equal to 8 Coma caused by severe TBI in age group 18-65 years Coma that lasted more than one week Condition and vital signs were stable Family members voluntarily agreed to let the participant participate in the study and signed an informed consent
Exclusion criteria
Exclusion criteria: 1. Individuals with recurrent brain injuries are not eligible for participation. 2. The presence of metallic implants or electronic devices in the brain or skull will disqualify participants. 3. Participants with trauma at the scalp will be excluded from the study. 4. Individuals younger than 18 years or older than 65 years will not be included. 5. Pregnant or lactating women are excluded from participation. 6. A history of epilepsy or seizure disorders will lead to exclusion. 7. Participants with pre-existing neurological or psychiatric disorders are not eligible. 8. Individuals with unstable hemodynamic conditions will be excluded. 9. Participants with severe organ failure (e.g., heart, liver, or kidney) are not eligible for the study. 10. Those with active infections requiring intravenous antibiotics will be excluded. 11. Chronic use of medications affecting consciousness or cognition will disqualify participants. 12. Individuals unable to undergo MRI or CT imaging will not be included. 13. Participants with fractures or injuries preventing safe positioning for stimulation are excluded. 14. Burns, wounds, or scalp lesions at the stimulation sites will lead to exclusion. 15. Individuals with penetrating head injuries are not eligible for participation. 16. Prior neuromodulation therapies will disqualify participants from the study. 17. Participants with intracranial hematomas or midline shift greater than 5 mm will be excluded. 18. Documented brain death will lead to exclusion from participation.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Glasgow Outcome Scale (GOS), Glasgow Coma Scale (GCS) ICU Mobility Scale, Coma Recovery Scale-Revised (CRS-R) Rancho Los Amigos ScaleTimepoint: Baseline, 2 weeks and 4 weeks | — |
Secondary
| Measure | Time frame |
|---|---|
| Western Neuro Sensory Stimulation ProfileTimepoint: Baseline, 2 weeks and 4 weeks | — |
Countries
India
Contacts
Public ContactDrYukta Ghugal
Ravi Nair Physiotherapy College
Outcome results
None listed