Health Condition 1: Z00-Z99- Factors influencing health status and contact with health services Health Condition 2: S069- Unspecified intracranial injury
Conditions
Interventions
Intervention1: Propranolol: Propranolol will be administered enterally or orally beginning at 20 mg TDS. It will be escalated by 20mg per dose (total 60 mg) daily if tolerated. End points ara a hear r
Sponsors
Swagata Tripathy
Eligibility
Inclusion criteria
Inclusion criteria: 1. Case of Traumatic Brain Injury 2. Age more than or equal to 18 3. GCS less than or equal to 12
Exclusion criteria
Exclusion criteria: 1. Head injury date more than 7 days 2. Case is pregnant 3. Case of active coronary syndrome 4. Non-survivable injury case(TBI with b/l dilated fixed pupils or shock within 24 hours of admission 5. Duration of hospital admission more than 72 hours 6. Penetrating type of injury 7. Heart rate less than 60 8. Presence of significant injury in another body region (Abbreviated Injury Scale score is more than 3
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Feasibility of delivering the dose once consent is gained and case if randomized. Inform of the effect size, safety and efficacy, funding will be sought for the next phase.Timepoint: Day 10, | — |
Secondary
| Measure | Time frame |
|---|---|
| 1. Association between beta-blocker therapy and in-hospital survival 2. Glasgow Outcome Scale Extended score 3. MortalityTimepoint: 1. Day of discharge 2. Day 28 post recruitment 3. Day 90 post recruitment 4. Day 180 post recruitment | — |
Countries
India
Contacts
Public ContactDr Swagata Tripathy
AIIMS Bhubaneswar
Outcome results
None listed