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Using Breathing Muscle Strength, Airway Pressure, and Lung Ultrasound to Predict Breathing Support Removal in Critically Ill Patients

Combination of respiratory muscle strength, P0.1 and lung ultrasound score to predict weaning failure from mechanical ventilation in critically ill patients: A prospective observational study. - CRPLUS trial

Status
Active, not recruiting
Phases
Unknown
Study type
Observational
Source
CTRI
Registry ID
CTRI/2025/03/083407
Enrollment
149
Registered
2025-03-25
Start date
Unknown
Completion date
Unknown
Last updated
2025-04-07

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: Z991- Dependence on respirator

Interventions

Intervention1: LUNG ULTRASOUND: Lung Ultrasound score, Respirstory Muscle Strength assessment by ultrasonography 30 mins after Spontaneous Breathing Trial Intervention2: Mechanical Ventilation: P0.1 v

Sponsors

Jadav Sainath
Lead Sponsor

Eligibility

Inclusion criteria

Inclusion criteria: Patient eligible for SBT after 48 hrs of mechanical ventilation in CCU Positive end-expiratory pressure less than or equal to 6 cm H2O Partial Pressure of Arterial Oxygen more than or equal to 60 mmHg with fraction of inspired oxygen less than 0.45 GCS more than 13 Richmond Agitation Sedation Scale -1 to +1 Body Temperature less than 38 degree Celsius Hematocrit level more than 21% or Hemoglobin level more than 7 g/dL No or low doses of vasopressor support

Exclusion criteria

Exclusion criteria: Patients with difficulty in obtaining ultrasound window Mechanical Ventilation less than 48 hrs History of Diaphragmatic Paralysis or Injury Ascites Thoracotomy Pneumothorax Pleural Effusion Thoracic Trauma History of Neuromuscular Disease Pregnant women Lactating or nursing mothers

Design outcomes

Primary

MeasureTime frame
To assess the power of the Combination of respiratory muscle strength, P0.1 and lung ultrasound score will predict weaning failure from mechanical ventilation in critically ill patients.Timepoint: 30 mins after Spontaneous Breathing Trial—

Secondary

MeasureTime frame
To assess Extubation failureTimepoint: Upto 48 hours after extubation;Requirement of noninvasive respiratory support after extubationTimepoint: Upto 48 hours after extubation—

Countries

India

Contacts

Public ContactJadav Sainath

Department of anaesthesia and critical care AIIMS Raipur

chinmaya.panda06@gmail.com8098007711

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026