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Comparing Magnesium Sulphate and Dexmedetomidine for Pain Relief After Knee Replacement Surgery Using Nerve Blocks

A comparative study between Magnesium Sulphate and Dexmedetomidine as adjuvant in combined ACB (Adductor Canal Block) and IPACK (Interspace between Popliteal Artery and Posterior Capsule of Knee Block) for post-operative analgesia after unilateral Total Knee Arthroplasty - NIL

Status
Active, not recruiting
Phases
Phase 3
Study type
Interventional
Source
CTRI
Registry ID
CTRI/2025/03/083361
Enrollment
98
Registered
2025-03-25
Start date
Unknown
Completion date
Unknown
Last updated
2025-04-07

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: O- Medical and Surgical

Interventions

Control Intervention1: Dexmeditomidine: All patients will be positioned for SAB. SAB with 2.8 ml of 0.5% Heavy bupivacaine with 60 micrograms of buprenorphine as adjuvant given using 25G Quincke spina

Sponsors

Dr Aruna Tegginmath
Lead Sponsor

Eligibility

Inclusion criteria

Inclusion criteria: Elective unilateral TKA Age between 40 to 75 years Belonging to ASA class 1 and 2 BMI less than 40 Patients with one or two comorbid conditions not interfering in their day to day life under control.

Exclusion criteria

Exclusion criteria: Patients who are contraindicated to regional anaesthesia Patients with any coagulopathies and bleeding disorder Infection at the site of block Hepatic or renal insufficiencies, Patients who are allergic to the drugs given in the study Regional anesthesia converted to general anaesthesia

Design outcomes

Primary

MeasureTime frame
Time to 1st request of analgesic (Duration of analgesia) To assess the NRS pain score at 4,8,12 and 24 hours both at rest and during ambulation To assess total analgesic requirement in the post-operative period for 24 hoursTimepoint: At 4,8,12 and 24 hours

Secondary

MeasureTime frame
1)To assess any adverse reactions following the procedure To assess the patient satisfactionTimepoint: Within 30 minutes & 48 hrs

Countries

India

Contacts

Public ContactAthira Girish

Dr. Moopens Medical College

shraddhakrupa27@gmail.com9243507325

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026