Transcranial Direct Current Stimulation (tDCS) as an Adjuvant Therapy in Patients with Late-Life Depression (LLD): A Single-Blind, Randomized, Sham-Controlled Trial

Transcranial Direct Current Stimulation (tDCS) as an Adjuvant Therapy in Patients with Late-Life Depression (LLD): A Single-Blind, Randomized, Sham-Controlled Trial - nil

Status

Active, not recruiting

Phases

Phase 2

Study type

Interventional

Source

CTRI

Registry ID

CTRI/2025/03/083323

Enrollment

Registered

2025-03-25

Start date

Unknown

Completion date

Unknown

Last updated

2025-04-07

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: F328- Other depressive episodes

Interventions

Intervention1: Transcranial Direct Current Stimulation: tDCS will be applied for 30 minutes, twice a day, for 5 days for patients diagnosed with late-life depression Control Intervention1: Transcrania

Eligibility

Inclusion criteria

Inclusion criteria: 1.60 years of age or older and diagnosed with Late Life Depression. 2. All patients who give valid consent

Exclusion criteria

Exclusion criteria: 1 Patients who are less than 60 years of age. 2. Other psychiatric comorbidities except mild anxiety. 3. Substance use disorder except tobacco. 4. High risk for suicide. 5. Serious brain diseases or unstable medical conditions that impairs decision taking capacity. 6. Any other significant communication barrier.

Design outcomes

Primary

Measure	Time frame
Assessment of efficacy of tDCS as an adjuvant to anti depressants in patients diagnosed with late life depression in comparison with sham controlled tDCS. Timepoint: 1 YEAR	—

Secondary

Measure	Time frame
1 To assess for rapid antidepressant effect of tDCS as an adjuvant to antidepressants in patients diagnosed with Late Life Depression. 2. To assess for the effect of tDCS on cognitive functions in patients diagnosed with Late Life DepressionTimepoint: 1 YEAR	—

Countries

India

Contacts

Public ContactJahanvi Zandawala

JAWAHARLAL NEHRU MEDICAL COLLEGE

sschate@gmail.com9880733499

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026