Health Condition 1: E08-E13- Diabetes mellitus
Conditions
Interventions
Intervention1: Dexmedetomidine: Intravenous Dexmedetomidine 0.5
mcg/kg over 20 minutes after induction of anaesthesia followed by 0.5 mcg/kg/hour continuous infusion till the deflation of pneumoperit
Sponsors
Jawaharlal Institute of Postgraduate Medical Education and Research
Eligibility
Inclusion criteria
Inclusion criteria: 1) Adults aged 18 to 70 years with diabetes mellitus with ASA PS 2 and 3 scheduled to undergo elective laparoscopic surgery under general anaesthesia. 2) Duration of pneumoperitoneum, minimum 2 hours and maximum 6 hours. 3) Preoperative baseline blood sugar value, less than 180 mg/dL
Exclusion criteria
Exclusion criteria: 1) Patients with known allergy to dexmedetomidine 2) Patients with severe cardiovascular disease or pulmonary disease, end-stage renal disease or decompensated liver disease.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| The number/percentage of patients requiring intraoperative insulinTimepoint: No specific time points for this outcome measure. Capillary blood sugar values will be measured at baseline, and then every hour after starting dexmedetomidine infusion till the end of surgery. Insulin infusion will be started if blood sugar value is found to be higher than 180mg/dL intraoperatively. | — |
Secondary
| Measure | Time frame |
|---|---|
| Hemodynamic parameters - Heart rate, blood pressure, mean arterial pressureTimepoint: every 5 minutes for 60 minutes after initiating drug infusion, and then every 15 minutes till the end of surgery and extubation;Serum cortisol and IL-6 levelsTimepoint: before induction of anaesthesia and just before deflation of pneumoperitoneum ;Incidence of hypoglycemiaTimepoint: | — |
Countries
India
Contacts
Public ContactDr Surya S
Jawaharlal Institute of Postgraduate Medical Education and Research (JIPMER)
Outcome results
None listed