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Comparative Study on Intravenous Cold Saline at Different Temperatures to Reduce Propofol Injection Pain: A Double-Blind RCT

Comparative evaluation of pretreatment with intravenous cold saline of three different temperatures prior propofol to attenuate propofol injection Pain: A Double-Blind, Randomized Controlled trial.

Status
Active, not recruiting
Phases
Unknown
Study type
Interventional
Source
CTRI
Registry ID
CTRI/2025/03/083202
Enrollment
1200
Registered
2025-03-24
Start date
Unknown
Completion date
Unknown
Last updated
2025-04-07

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: O- Medical and Surgical

Interventions

Intervention1: Group II: Pretreatment with 5 ml of normal saline intravenously at 15 C temperature before Propofol injection Intervention2: normal saline intravenously at 10 C: Pretreatment with 5 ml

Sponsors

SANJAY GANDHI POST GRADUATE INSTITUTE OF MEDICAL SCIENCES LUCKNOW
Lead Sponsor

Eligibility

Inclusion criteria

Inclusion criteria: physical status of ASA I-II scheduled for elective surgery under general anesthesia

Exclusion criteria

Exclusion criteria: 1. History of any drug allergies or use of analgesic medication within 24 h before surgery 2. Any organ dysfunction and neurological disease and mental disorders

Design outcomes

Primary

MeasureTime frame
the overall incidence and severity of pain after propofol injectionTimepoint: Immediately after propofol injection (Single time point)

Secondary

MeasureTime frame
Hemodynamic changesTimepoint: at the time of injection of cold saline;Incidence of discomfortTimepoint: at the time of injection of cold saline;Phlebitis any, in the treated veinTimepoint: Followed for one week.

Countries

India

Contacts

Public ContactDR DEVENDRA GUPTA

Sanjay Gandhi Post-Graduate Institute of Medical Sciences, Lucknow

drdevendragpt@yahoo.com09919754895

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026