Clinical trial to study the effects of hyaluronic acid, i- PRF and combination of both on patients with thin periodontal phenotype

Evaluation of efficacy of hyaluronic acid, i-PRF and combination of both through VISTA approach in the management of thin periodontal phenotype- A Randomized clinical trial ( RCT) - NIL

Status

Active, not recruiting

Phases

Phase 3Phase 4

Study type

Interventional

Source

CTRI

Registry ID

CTRI/2025/03/083146

Enrollment

Registered

2025-03-24

Start date

Unknown

Completion date

Unknown

Last updated

2025-04-07

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: O- Medical and Surgical Health Condition 2: K055- Other periodontal diseases Health Condition 3: K055- Other periodontal diseases

Interventions

Intervention1: Hyaluronic acid: 1.5 % injectable hyaluronic acid 0.25 ml per site Intervention2: i- PRF: Injectable PRF got by centrifuging 5 ml patients blood at 700 rpm for 4 minutes Intervention3:

Eligibility

Inclusion criteria

Inclusion criteria: 1 Participants diagnosed with thin gingival phenotype. gingival thickness less than or equal to 1 mm 2 Participants willing to participate in the study

Exclusion criteria

Exclusion criteria: 1 Systemically compromised patients 2 Heavy smokers 3 Pregnant or lactating woman 4 Patients who have been previously undergone periodontal therapy 5 Patients with active orthodontic treatment 6 Aggressive or chronic periodontitis 7 Patients with known allergy to hyaluronic acid

Design outcomes

Primary

Measure	Time frame
To evaluate the efficacy of Hyaluronic acid, i-PRF and combination of both through VISTA approach on thin periodontal phenotype.Timepoint: Gingival thickness, Keratinized tissue width at time points baseline, 1 month, 3 months and 6 months. Buccal bone thickness at time points baseline and six months	—

Secondary

Measure	Time frame
To evaluate the efficacy of Hyaluronic acid through VISTA approach in the management of thin periodontal phenotype To evaluate the efficacy of i-PRF through VISTA approach in the management of thin periodontal phenotype To evaluate the efficacy of combination of hyaluronic acid and i-PRF through VISTA approach in the management of thin periodontal phenotype Timepoint: Gingival thickness, Keratinized tissue width, Plaque index, Gingival index, Bleeding on probing, Probing depth and Clinical attachment level time point-baseline, one month, three months and six months. Buccal bone thickness at crest and at midbuccal level time point- baseline and 6 months	—

Measure

Time frame

To evaluate the efficacy of Hyaluronic acid through VISTA approach in the management of thin periodontal phenotype To evaluate the efficacy of i-PRF through VISTA approach in the management of thin periodontal phenotype To evaluate the efficacy of combination of hyaluronic acid and i-PRF through VISTA approach in the management of thin periodontal phenotype Timepoint: Gingival thickness, Keratinized tissue width, Plaque index, Gingival index, Bleeding on probing, Probing depth and Clinical attachment level time point-baseline, one month, three months and six months. Buccal bone thickness at crest and at midbuccal level time point- baseline and 6 months

—

Countries

India

Contacts

Public ContactDr Anuradha Bhatsange

Jawahar Medical Foundations Annasaheb Chaudaman Patil Memorial dental college, Dhule

anujaps219@gmail.com7020927361

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026