Effect of SGLT2 Inhibitors on Kidney Function in People with Diabetes: A Clinical Study

Effect of SGLT2 Inhibitors on Renal Resistive Index in Diabetic Nephropathy Patients : A Quasi-Experimental Study - NIL

Status

Active, not recruiting

Phases

Phase 2

Study type

Interventional

Source

CTRI

Registry ID

CTRI/2025/03/083103

Enrollment

148

Registered

2025-03-21

Start date

Unknown

Completion date

Unknown

Last updated

2025-04-07

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: E112- Type 2 diabetes mellitus with kidney complications

Interventions

Intervention1: SGLT2 Inhibitors in Diabetic Nephropathy Patients , that is their effect on various parameters.Here two parameters whose response to SGLT2 Inhibitors (T.DAPAGLIFOZIN 10mg once daily)is

Eligibility

Inclusion criteria

Inclusion criteria: Inclusion criteria includes patients with Type 2 diabetes mellitus whose Blood pressure is controlled that is within 140/90mmHg , urine albumin creatinine ratio within 300 , estmated glomerular filtration rate more than 60ml/min/1.73 meter square and patient treated with other oral antihyperglycemic agents other than SGLT2 inhibitors

Exclusion criteria

Exclusion criteria: Exclusion criteria includes patients with obstructive uropathy , co existent renal pathologies or anomalies , on nephrotoxic drugs , patients with refractory hypertension , patients already on SGLT2 inhibitors and insulin , patients with severe hepatic insufficiency , recurrent urinary tract infection , peripheral vascular disease , fever , infection , menstruating females and excluding females who are within 7 days pre and post menstrual cycle.

Design outcomes

Primary

Measure	Time frame
SGLT2 inhibitors ( T.DAPAGLIFOZIN 10mg once daily) contribute to a significant reduction in renal resistive index and urine albumin creatinine ratio , suggesting their potential as a therapeutic option for slowing the progression of diabetic nephropathyTimepoint: Primary outcome assessed at 3 months following the start of the drug(T.DAPAGLIFOZIN 10mg once daily)	—

Secondary

Measure	Time frame
Renal resistive index can detect diabetic nephropathy much earlier than urine Albumin Creatinine Ratio. Here in my study if the Renal Resistive index is high(0.7) for a type 2 Diabetes mellitus patient with urine Albumin Creatinine Ratio within 30mg/g of creatinine which within normal limits , secondary outcome of the study which is to be obtained is that Renal Resistive Index is an effective tool for detecting early diabetic nephropathy & it can be used to follow up diabetic nephropathy.Timepoint: secondary outcome assessed at the end of three months	—

Measure

Time frame

Renal resistive index can detect diabetic nephropathy much earlier than urine Albumin Creatinine Ratio. Here in my study if the Renal Resistive index is high(0.7) for a type 2 Diabetes mellitus patient with urine Albumin Creatinine Ratio within 30mg/g of creatinine which within normal limits , secondary outcome of the study which is to be obtained is that Renal Resistive Index is an effective tool for detecting early diabetic nephropathy & it can be used to follow up diabetic nephropathy.Timepoint: secondary outcome assessed at the end of three months

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Countries

India

Contacts

Public ContactChandni Jayakumar

SRM Medical College Hospital and Research Centre

cj2788@srmist.edu.in8089758662

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026