Effect of inhaled milrinone on oxygenation and right ventricular function in patient with acute respiratory distress syndrome on mechanical ventilation - A prospective Randomized controlled trial .

Effect of inhaled milrinone on oxygenation and right ventricular function in patient with acute respiratory distress syndrome on mechanical ventilation - A prospective randomized controlled trial .

Status

Recruiting

Phases

Phase 2Phase 3

Study type

Interventional

Source

CTRI

Registry ID

CTRI/2025/03/083079

Enrollment

Registered

2025-03-21

Start date

Unknown

Completion date

Unknown

Last updated

2025-09-15

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: J20-J22- Other acute lower respiratory infections

Interventions

Intervention1: GROUP M: Group M will receive Milrinone nebulization 3mg (1mg/1ml ) every 6 hours from Day 1 to 3 after randomization. Neb.Milrinone 3mg TDS for 3days. Control Intervention1: GROUP N: G

Eligibility

Inclusion criteria

Inclusion criteria: Age 18 , intubated and mechanically ventilated ARDS patient as defined by Berlin criteria of any cause , PF ratio less than 300 and within 72hrs of mechanical ventilation

Exclusion criteria

Exclusion criteria: 1.Already on pulmonary vasodilator 2. Known case of tachy-arrythmia 3.Patient on ECMO 4.Pregnant patient or lactating mother 5.Patient refusal

Design outcomes

Primary

Measure	Time frame
To evaluate the effect of inhaled milrinone on average mean PF ratio (oxygenation parameter) , which measures every 12hours once till 72hours after enrollmentTimepoint: DAY 1 TO 3	—

Secondary

Measure	Time frame
1)Oxygenation index from days 0 to 3 every 12hours. 2)PaO2 & PaCO2 from day 0 to 3 every 12 hours. 3) intrapulmonary shunt fraction (Qs/Qt) from day 0 to 3 every 12 hours. 4) Lung injury score, plateau pressure, driving pressure baseline value, 24hrs & 72hrs after enrollment. 5)Echocardiography parameter both RV & LV systolic function baseline value, 24hrs & 72hrs after enrollment. 6) Number of prone sessions. 7) Trop I & Pro-BNP levels baseline value & 72hrs after enrollment Timepoint: DAY 1 to 3	—

Measure

Time frame

1)Oxygenation index from days 0 to 3 every 12hours. 2)PaO2 & PaCO2 from day 0 to 3 every 12 hours. 3) intrapulmonary shunt fraction (Qs/Qt) from day 0 to 3 every 12 hours. 4) Lung injury score, plateau pressure, driving pressure baseline value, 24hrs & 72hrs after enrollment. 5)Echocardiography parameter both RV & LV systolic function baseline value, 24hrs & 72hrs after enrollment. 6) Number of prone sessions. 7) Trop I & Pro-BNP levels baseline value & 72hrs after enrollment Timepoint: DAY 1 to 3

—

Countries

India

Contacts

Public ContactDR NISHANT PATEL

AIIMS, NEW DELHI

pateldrnishant@gmail.com8510955882

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026