Treatment of gum diseases using a herbal apple rind gel

EVALUATION OF CLINICAL EFFICACY OF LOCALLY DELIVERED NOVEL GEL CONTAINING GREEN APPLE RIND EXTRACT AS AN ADJUNCT TO NON-SURGICAL PERIODONTAL THERAPY - NIL

Status

Active, not recruiting

Phases

Phase 4

Study type

Interventional

Source

CTRI

Registry ID

CTRI/2025/03/083051

Enrollment

Registered

2025-03-21

Start date

Unknown

Completion date

Unknown

Last updated

2025-04-07

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: K053- Chronic periodontitis

Interventions

Intervention1: Scaling and root planing followed by Local delivery of Green Apple Rind extract gel: After baseline examination, the test sites will be treated with SRP followed by subgingival adminis

Eligibility

Inclusion criteria

Inclusion criteria: 1. Systemically healthy patients within the age group of 18 65 years. 2. Patients should have at least 14 natural teeth in the oral cavity. 3. Patients with no history of allergies. 4. Patients who are diagnosed with generalised periodontitis of stages II and III (according to the 2017 World Workshop of Periodontology) with bilateral periodontal pockets with probing pocket depth of between 4 and 6 mm.

Exclusion criteria

Exclusion criteria: 1. Smokers. 2. Pregnant and lactating mothers. 3. Patients who received radiotherapy, chemotherapy or immunosuppressive treatment, systemic corticosteroids, and/or anticoagulants 30 days prior to intervention. 4. Patients with any systemic disease. 5. Patients under the influence of non-steroidal anti-inflammatory drugs (NSAIDS) or any other anti-inflammatory medications, antibiotics, steroids that can alter the course of periodontitis progression and treatment.

Design outcomes

Primary

Measure	Time frame
locally delivered novel gel containing green apple rind extract when delivered as an adjunct to SRP in the treatment of periodontitis positvely influences the Plaque Index, Gingival Index, Sulcus Bleeding Index, Probing pocket Depth , Clinical Attachment level and gingival parameters including the colour, contour, consistency, surface texture, position and width of keratinized tissueTimepoint: Baseline, 3 months and 6 months	—

Measure

Time frame

locally delivered novel gel containing green apple rind extract when delivered as an adjunct to SRP in the treatment of periodontitis positvely influences the Plaque Index, Gingival Index, Sulcus Bleeding Index, Probing pocket Depth , Clinical Attachment level and gingival parameters including the colour, contour, consistency, surface texture, position and width of keratinized tissueTimepoint: Baseline, 3 months and 6 months

—

Secondary

Measure	Time frame
comparison of Patient reported outcome measures (PROMS) in both the treatment groupsTimepoint: baseline, 3 months and 6 months	—

Countries

India

Contacts

Public ContactDr Pranjali Bawankar

Ranjeet Deshmukh Dental College and Research Center, Nagpur

Drpranjalibawankar@gmail.com9975128729

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026