Health Condition 1: N970- Female infertility associated withanovulation Health Condition 2: E282- Polycystic ovarian syndrome
Conditions
Interventions
Intervention1: myoinositol and d-chiro inositol: Study group will be treated with myoinositol and d-chiro inositol 2255 mg OD for 3 months
Control Intervention1: metformin: The control group will be t
Sponsors
Jawaharlal Institute of Postgraduate Medical Education & Research(JIPMER)
Eligibility
Inclusion criteria
Inclusion criteria: All infertile women with PCOS (Diagnosed according to Rotter-dam s criteria) attending the infertility clinic/OPD at Women and Children Hospital, JIPMER: 1)Age of the Women: between 21 to 35 years 2) Women with PCOS according to Rotterdam 2003 criteria 3) Willing for regular follow-up
Exclusion criteria
Exclusion criteria: A woman who is a known case of 1) Thyroid disorders 2) Congenital adrenal hyperplasia 3) Adrenal tumors 4) Cushing syndrome 5) Presence of any chronic diseases eg; diabetes mellitus, Chronic kidney disease, liver disease, etc. 6) Women who are allergic to metformin or inositols 7) Patient on metformin therapy 8) Women on steroid therapy or Oral contraceptive pills usage for within three months
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| To assess the effect of metformin and myoinositol+ d-chiro inositol on meta-bolic parameter - HOMA IR in infertile women with PCOS.Timepoint: from the day of entry to study and follow up visits at 4 weeks, 8 weeks and 12 weeks | — |
Secondary
| Measure | Time frame |
|---|---|
| To determine and compare the effects of Metformin and myoinositol with d-chiro inositol on - Clinical parameters, Hormonal parameters, Metabolic parameters, USG parameters, Quality of life- PCOSQOL scale Timepoint: from the day of entry to study and follow up visits at 4 weeks, 8 weeks and 12 weeks | — |
Countries
India
Contacts
Public ContactDr Ann Sara Jacob
Jawaharlal Institute of Postgraduate Medical Education & Research(JIPMER)
Outcome results
None listed