A clinico-microbial study comparing the effectiveness of antimicrobial photodynamic therapy mediated by indocyanine green and methylene blue as an adjunct to non surgical periodontal therapy

COMPARATIVE EVALUATION OF EFFICACY OF INDOCYANINE GREEN AND METHYLENE BLUE MEDIATED ANTIMICROBIAL PHOTODYNAMIC THERAPY AS AN ADJUNCT TO NON-SURGICAL TREATMENT OF PERIODONTITIS. A CLINICO-MICROBIAL STUDY - NIL

Status

Active, not recruiting

Phases

Phase 3

Study type

Interventional

Source

CTRI

Registry ID

CTRI/2025/03/083028

Enrollment

Registered

2025-03-21

Start date

Unknown

Completion date

Unknown

Last updated

2026-09-14

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: K053- Chronic periodontitis

Interventions

Intervention1: Indocyanine green: Photosensitizing agent Control Intervention1: Methylene Blue: Photosensitizing agent

Eligibility

Inclusion criteria

Inclusion criteria: Patients with minimum 20 teeth. Patients with Stage II Grade A periodontitis having at least 3 teeth with probing depth of 5 mm.

Exclusion criteria

Exclusion criteria: Consumption of tobacco in any form. Pregnant and lactating women. Patients taking medications that may interfere with periodontal therapy. Previous history of allergic reaction to the use of any kind of dye.

Design outcomes

Primary

Measure	Time frame
Plaque index Gingival index Probing pocket depth Clinical attachment levelTimepoint: At baseline, 1 and 3 months	—

Secondary

Measure	Time frame
Microbial analysis of total viable anaerobic count (TVAC)Timepoint: At baseline, 1 and 3 months	—

Countries

India

Contacts

Public ContactDr K SUNEETHA

Drs. Sudha and Nageswara rao Siddartha institute of dental sciences

ksuneetha@sids.edu.in9290574051

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Sep 19, 2026