Comparative Efficacy of Levosimendan and Milrinone in Catecholamine-Resistant Septic Shock with Myocardial Dysfunction in Children: A Single-Center, Open-Label RCT

Comparison Of Efficacy Of Levosimendan Versus Milrinone In Catecholamine Resistant Septic Shock With Myocardial Dysfunction In Children : A Single-Center, Open-Label Randomized controlled Trial - Nil

Status

Active, not recruiting

Phases

Phase 2

Study type

Interventional

Source

CTRI

Registry ID

CTRI/2025/03/083025

Enrollment

Registered

2025-03-21

Start date

Unknown

Completion date

Unknown

Last updated

2025-04-07

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: I958- Other hypotension

Interventions

Intervention1: levosimendan: Drug levosimendan @ 0.05mcg/kg/min. After 15 min if no response then increase Drug levosimendan @ 0.1mcg/kg/min After 15 min if no response then increase Drug levosimen

Eligibility

Inclusion criteria

Inclusion criteria: All the patients admitting in Paediatric emergency and pediatric intensive care unit, AIIMS Patna, with diagnosis of catecholamine resistant septic shock with and cardiac Index less than 3.3L/MIN/M2

Exclusion criteria

Exclusion criteria: Patient requiring CPR at presentation Cardiomyopathy, cardiothoracic surgery within the previous 14 days. congenital heart disease

Design outcomes

Primary

Measure	Time frame
improvement of cardiac function based on fractional shortening and cardiac index (by 2D ECHO), Heart rate & Blood pressure (age & sex adjusted), lactate levels. Timepoint: 1 DAY	—

Secondary

Measure	Time frame
Time taken for improvement in cardiac function, survival outcome. Timepoint: AT DISCHARGE	—

Countries

India

Contacts

Public ContactPawan Kumar

AIIMS, Patna

drarunp@aiimspatna.org7005783748

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026