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A randomized, double-blind study comparing the effectiveness of inhaled dexmedetomidine versus lidocaine in minimizing coughing and discomfort during extubation (breathing tube removal) following general anesthesia for surgery.

COMPARISON OF IN-LINE NEBULISATION WITH DEXMEDETOMIDINE VERSUS 2% XYLOCARD PRIOR TO EXTUBATION ON EXTUBATION RESPONSE IN PATIENTS UNDERGOING SURGERY UNDER GENERAL ANAESTHESIA- A RANDOMIZED DOUBLE BLIND CLINICAL TRIAL. - NIL

Status
Active, not recruiting
Phases
Unknown
Study type
Interventional
Source
CTRI
Registry ID
CTRI/2025/03/082972
Enrollment
90
Registered
2025-03-20
Start date
Unknown
Completion date
Unknown
Last updated
2025-04-07

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

None listed

Interventions

Intervention1: DEXMEDETOMIDINE NEBULISATION: Dexmedetomidine is a highly selective alpha 2-adrenoreceptor agonist, which possesses hypnotic, sedative, anxiolytic, sympatholytic, and analgesic properti

Sponsors

NIZAMS INSTITUTE OF MEDICAL SCIENCES
Lead Sponsor

Eligibility

Inclusion criteria

Inclusion criteria: Written and valid consent ASA I and II Age 18 to 60 years Patients undergoing surgery under General Anaesthesia Duration less than 3 hours

Exclusion criteria

Exclusion criteria: Patient refusal Chronic smokers more than 20 pack years Patients with compromised cardiopulmonary respiratory status requiring special anaesthetic plan Head and neck surgery Any known allergy to the study drugs

Design outcomes

Primary

MeasureTime frame
To assess and compare cough response in different groups during extubation.Timepoint: T0 Point at which sevoflurane is cut off T1 Point where reversal agent is given T2 2 mins after administration of reversal TE Point of extubation T3 2 mins after extubation T4 5 mins after extubation T5 10 mins after extubation—

Secondary

MeasureTime frame
To assess & compare the hemodynamic changes during extubationTimepoint: Point at which sevoflurane is cut off Point at which reversal agent is given 2 mins after reversal Point of extubation 2 mins after extubation 5 mins after extubation 10 mins after extubation;To assess emergence agitationTimepoint: Point at which sevoflurane is cut off Point at which reversal agent is given 2 mins after reversal Point of extubation 2 mins after extubation 5 mins after extubation 10 mins after extubation;To assess any complications, post extubation like stridor due to laryngospasm or any other cause, vomiting, wheeze, desaturation, pulmonary edemaTimepoint: Point at which sevoflurane is cut off Point at which reversal agent is given 2 mins after reversal Point of extubation 2 mins after extubation 5 mins after extubation 10 mins after extubation;Duration of recovery - the time between the point where sevoflurane is cut off & the point where extubation is doneTimepoint: Point at which sevoflurane is cut off Point at which reversal agent is given 2 mins after reversal Point of extubation 2 mins after extubation 5 mins after extubation 10 mins after extubation—

Countries

India

Contacts

Public ContactDR MADHU PRIYA V

NIZAMS INSTITUTE OF MEDICAL SCIENCES

drgeeta3007@gmail.com9849264451

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026