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Comparison between the effects of propofol and thiopentone as an induction agent

A prospective single blinded randomized study comparing the effects of propofol and thiopentone as an induction agent on hemodynamic changes during induction and endotracheal intubation - NIL

Status
Active, not recruiting
Phases
Unknown
Study type
Interventional
Source
CTRI
Registry ID
CTRI/2025/03/082901
Enrollment
134
Registered
2025-03-20
Start date
Unknown
Completion date
Unknown
Last updated
2025-04-07

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: O- Medical and Surgical

Interventions

Intervention1: THIOPENTONE: Patients will be divided into two groups group A will receive propofol(2mg/kg) and the group B will receive thiopentone(5mg/kg) as induction agent for tracheal intubation d

Sponsors

SRM Medical College And Hospital
Lead Sponsor

Eligibility

Inclusion criteria

Inclusion criteria: Patient belonged to ASA 1 and 2 Patient undergoing elective surgeries with endotracheal intubation

Exclusion criteria

Exclusion criteria: Patient belonged to ASA 3 and 4 Patient with systemic illness Patient with uncontrolled hypertension Airway related surgery Pregnancy patient

Design outcomes

Primary

MeasureTime frame
To assess the changes in mean arterial pressure, blood pressure, oxygen saturation, and heart rateTimepoint: 0 Minutes 1 Minutes 3 Minutes 5 Minutes 10 Minutes

Secondary

MeasureTime frame
The secondary outcomes of this study include the incidence of adverse events such as arrhythmias laryngospasm & airway reflex responses induction characteristics including time to loss of consciousness & pain on injection & ease of intubation assessed by Cormack Lehane grading & the number of attempts required & recovery parameters such as the time for mean arterial pressure & heart rate to normalize along with post induction side effectsTimepoint: 0 minutes 1 minutes 3 minutes 5 minutes 10 minutes

Countries

India

Contacts

Public ContactDr Natarajan B

SRM Medical College and Hospital SRM Nagar Potheri

Natarajb2@srmist.edu.in9790872056

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026