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Comparing the Effects of Two Medicines, Esmolol and Labetalol, on Heart rate and Blood Pressure Control During Breathing Tube Removal After Surgery

A randomised study to compare the effects of i.v Esmolol vs i.v Labetalol in attenuating hemodynamic response during extubation in Department of Anesthesia, S.M.S Medical College Jaipur - nil

Status
Active, not recruiting
Phases
Phase 3
Study type
Interventional
Source
CTRI
Registry ID
CTRI/2025/03/082812
Enrollment
100
Registered
2025-03-19
Start date
Unknown
Completion date
Unknown
Last updated
2025-04-07

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: - Health Condition 2: K400- Bilateral inguinal hernia, with obstruction, without gangrene

Interventions

Intervention1: Inj. Esmolol: 1.5mg/kg Intravenous drug is given once, 2mins before extubation and observed over a period of 10 mins Control Intervention1: Inj. Labetalol: 0.25mg/kg Intravenous drug is

Sponsors

Sawai man singh medical college
Lead Sponsor

Eligibility

Inclusion criteria

Inclusion criteria: 1.Patients giving consent for general anaesthesia 2.Adult patients of either sex

Exclusion criteria

Exclusion criteria: 1.Patients posted for emergency surgery 2.Physical status ASA Class III or more 3.Patients having any significant systemic disorder 4.Patients having comorbid diseases

Design outcomes

Primary

MeasureTime frame
Heart rateTimepoint: baseline, after giving reversal, at the end of drug administration, 1 min after administration, at the time of extubation, after extubation

Secondary

MeasureTime frame
systolic bp, diastolic bp, mean arterial bpTimepoint: baseline, after giving reversal, at the end of drug administration, 1 min after administration, at the time of extubation, after extubation

Countries

India

Contacts

Public ContactDr Snehal Dudekula

Sawai Man Singh Medical College and Hospital, Jaipur

dr.shriphal@gmail.com9928350391

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026