Health Condition 1: N970- Female infertility associated withanovulation
Conditions
Interventions
Intervention1: Yoga: 12-week Yoga-based Lifestyle Modification Program (YLMP)
Control Intervention1: Controls: Not applicable
Sponsors
Dr Rima Dada
Eligibility
Inclusion criteria
Inclusion criteria: confirmed PCOS diagnosis based on the Rotterdam consensus, age between 15 and 40 years, Indian ethnicity, and willingness to provide consent.
Exclusion criteria
Exclusion criteria: Participants unable to attend follow-ups and provide consent, along with those having inflammatory arthritis, lower limb pathologies hindering yoga participation, known causes of infertility and androgen excess, severe endometriosis, severe male factor infertility, and documented severe tubal bilateral pathology.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| To assess hormonal profileTimepoint: 1 years | — |
Secondary
| Measure | Time frame |
|---|---|
| 1. To assess metabolomic profiles in pre- and post-Yoga interventions in PCOS, compared to healthy controls (HC). 2.To investigate changes in the transcriptome profile using NGS and validate active transcripts through RT-PCR at pre- and post-yoga intervention in PCOS, compared to HC. 3.To evaluate gut microbiota dysbiosis profiling using NGS pre- and post-yoga intervention in PCOS, compared to HC. 4.To validate identified transcriptomics using yoga-primed serum in PCOS-specific cell lines (GCP-01 and KGN cell line).Timepoint: 1,2,3,4 objectives - 1-3 years | — |
Countries
India
Contacts
Public ContactDr Rima Dada
AIIMS, New delhi
Outcome results
None listed