Health Condition 1: M959- Acquired deformity of musculoskeletal system, unspecified
Conditions
Interventions
Intervention1: STUDY GROUP
Patients with Alcohol Use Disorder requiring surgery for facial fracture: Intervention agent - alcohol 40% ABV in the postoperative period
Dose and duration - (0.5gm/kg b
Sponsors
Elavenil Panneerselvam
Eligibility
Inclusion criteria
Inclusion criteria: -ASA grade III (American Society of Anesthesiologists - physical status classification system) patients, due to alcohol use disorder -Patients with established Alcohol Use Disorder (AUD) according to DSM-5 (Diagnostic & Statistical Manual of Mental Disorders) Criteria – mild & moderate grade -Patients with intake of atleast 60 g of ethanol (150ml of distilled spirit ) per day for at least 1 yr preoperatively -AUDIT (Alcohol Use Disorder Identification Test by WHO) scale – risk zone 1, 2, 3 -Patients with fractures of the mandible -Patients who are responsive with GCS score of 15 and ambulatory -Patients belonging to upper lower and lower middle class according to modified Kuppuswamy socioeconomic status Patients and family consenting for the study
Exclusion criteria
Exclusion criteria: Patients lesser than 21 years and greater than 50 years. -Patients with head injury and poly trauma -Patients with systemic problems which compromises wound healing -Patients with drinking in moderation (2drinks or less in a day for men; 1 drink or less for women according to National Institute on Alcohol Abuse and Alcoholism) -Patients with smoking -Patients who are non-compliant to the peri-operative protocol -AUDIT zone 4, CIWA-severe grade (Clinical Institute Withdrawal Assessment of Alcohol Scale) -AST/ALT ratio more than 2 (AST- aspartate aminotransferase; ALT- alanine aminotransferase) -Patients developing AWS (Alcohol Withdrawal Syndrome) after admission
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| 1. To evaluate peri operative stress levels 2. To evaluate quality of lifeTimepoint: 1. Post trauma, postoperative day 1 and postoperative 1,2,4,6 weeks 2. Post trauma, postoperative day 1 and postoperative 1,2,4,6 weeks | — |
Secondary
| Measure | Time frame |
|---|---|
| 3. To evaluate soft tissue healing 4. To evaluate fracture healing 4.a biochemical evaluation 4.b ImagingTimepoint: 3. 7th, 14th and 21st postoperative days 4.a Preoperative and 30th postoperative day 4.b Preoperative, 4th and 8th week postoperatively | — |
Countries
India
Contacts
Public ContactElavenil Panneerselvam
SRM Dental College and Hospital
Outcome results
None listed