Health Condition 1: S062- Diffuse traumatic brain injury
Conditions
Interventions
Control Intervention1: NIL: NIL
Sponsors
National Institute of Mental Health and Neuro Sciences
Eligibility
Inclusion criteria
Inclusion criteria: Patients with focal and diffuse TBI of moderate and severe grades based on GCS of 3 to 12 Age 18 to 75 years Admission within 72 hours of injury
Exclusion criteria
Exclusion criteria: Mild TBI GCS 13 to 15 Patients on beta blockers or multiple organ failure or large dose of inotropes Bradycardia Pregnancy Refusal of consent Unknown patient Uncooperative patient
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| To determine the incidence, predictors of autonomic dysfunction and trend of change in HRV during acute phase of TBI.Timepoint: on admission, at 48 hours, at 72 hours. | — |
Secondary
| Measure | Time frame |
|---|---|
| 1.To determine the incidence and predictors of inflammatory burden - assessed using novel markers MAR and LAR in addition to NAR. 2. Correlation between autonomic dysfunction percentage and inflammatory marker levels. 3. Effect of autonomic dysfunction and inflammation on the incidence of major adverse cardiac events (MACE), and other outcomes such as duration of hospital stay, GCS at discharge, and in-hospital mortality in patients with TBI. Timepoint: At admission | — |
Countries
India
Contacts
Public ContactDR K R MADHUSUDAN REDDY
national institute of mental health and neuro sciences
Outcome results
None listed