Comparison of Combining IV Ketamine and IV Propofol (Ketofol) versus IV Propofol Alone for Anesthesia in Patients with Brain Tumors

Comparison of combination of IV ketamine and IV propofol (Ketofol) versus IV propofol anaesthesia in supratentorial intracranial space occupying lesion: A Randomised Controlled Pilot Study - NIL

Status

Active, not recruiting

Phases

Phase 2

Study type

Interventional

Source

CTRI

Registry ID

CTRI/2025/03/082681

Enrollment

Registered

2025-03-19

Start date

Unknown

Completion date

Unknown

Last updated

2025-04-07

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: R900- Intracranial space-occupying lesion found on diagnostic imaging of central nervous system

Interventions

Intervention1: Group KP: 1.Patient will be allocated by randomisation method into two groups. 2.Patients in group KP will receive Inj. Ketamine and Propofol in ratio of 1:5 by weight and Patients in

Eligibility

Inclusion criteria

Inclusion criteria: 1.Patients undergoing Supratentorial Intracranial Space Occupying lesion surgery under general anaesthesia. 2.Patients consenting for the procedure

Exclusion criteria

Exclusion criteria: 1.Unconscious patient 2.Patients with features of raised intracranial pressure. 3.Coronary Heart Disease 4.Psychiatric Disease and Neurodegenerative disorders. 5.Known allergies to study drugs

Design outcomes

Primary

Measure	Time frame
To evaluate quality of brain relaxation between combination of injection Ketamine and injection Propofol (KETOFOL) and Injection Propofol by utilizing Brain relaxation score just after opening of duramater.Timepoint: To evaluate quality of brain relaxation between combination of injection Ketamine and injection Propofol (KETOFOL) and Injection Propofol by utilizing Brain relaxation score just after opening of duramater.	—

Measure

Time frame

To evaluate quality of brain relaxation between combination of injection Ketamine and injection Propofol (KETOFOL) and Injection Propofol by utilizing Brain relaxation score just after opening of duramater.Timepoint: To evaluate quality of brain relaxation between combination of injection Ketamine and injection Propofol (KETOFOL) and Injection Propofol by utilizing Brain relaxation score just after opening of duramater.

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Secondary

Measure	Time frame
To compare the haemodynamic stability during induction & maintenance of anaesthesia between combination of injection Ketamine & injection Propofol (KETOFOL) & injection Propofol by measuring various haemodynamic variables (mean arterial pressure, heart rate, end tidal carbon dioxide) at start of surgery, just after intubation, 1 min after intubation, 5 mins after intubation, 10 mins after intubation, post operative period.Timepoint: To compare the haemodynamic stability during induction & maintenance of anaesthesia between combination of injection Ketamine & injection Propofol (KETOFOL) & injection Propofol by measuring various haemodynamic variables (mean arterial pressure, heart rate, end tidal carbon dioxide) at start of surgery, just after intubation, 1 min after intubation, 5 mins after intubation, 10 mins after intubation, post operative period.	—

Measure

Time frame

To compare the haemodynamic stability during induction & maintenance of anaesthesia between combination of injection Ketamine & injection Propofol (KETOFOL) & injection Propofol by measuring various haemodynamic variables (mean arterial pressure, heart rate, end tidal carbon dioxide) at start of surgery, just after intubation, 1 min after intubation, 5 mins after intubation, 10 mins after intubation, post operative period.Timepoint: To compare the haemodynamic stability during induction & maintenance of anaesthesia between combination of injection Ketamine & injection Propofol (KETOFOL) & injection Propofol by measuring various haemodynamic variables (mean arterial pressure, heart rate, end tidal carbon dioxide) at start of surgery, just after intubation, 1 min after intubation, 5 mins after intubation, 10 mins after intubation, post operative period.

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Countries

India

Contacts

Public ContactDr Ajit Bhardwaj

Armed Forces Medical College

rainaajit@gmail.com8171505533

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026