Health Condition 1: C139- Malignant neoplasm of hypopharynx,unspecified Health Condition 2: C329- Malignant neoplasm of larynx, unspecified
Conditions
Interventions
Intervention1: radiation treatment: extra fraction of radiation per week, i.e patient receives 6 days a week radiotherapy , one extra dose on saturday every week instead of regular 5 days a week treat
Sponsors
Cancer Institute Adyar WIA
Eligibility
Inclusion criteria
Inclusion criteria: 1.All patients of newly diagnosed locally advanced stage III-IV squamous cell carcinomas of hypopharynx and larynx subsite, not for surgery, eligible to receive Radical radiotherapy with or without chemotherapy. 2.Age between 18 to 75 years
Exclusion criteria
Exclusion criteria: 1.Patients with distant metastatic disease 2.Those who have undergone surgery and recurrent disease status. Patient is mentally incapacitated or has a significant emotional aspect
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| The primary end point would be treatment completion rates (proportion of patients completing the planned treatment) for feasibility 2.The proportion of patients who develop Grade 3 and 4 toxicity as per RTOG/CTCAE criteria.Timepoint: The treatment completion rates (proportion of patients completing the planned treatment) will be assessed at the end of radiotherapy treatment 2.The proportion of patients who develop Grade 3 and 4 toxicity as per RTOG/CTCAE criteria will be assessed every week during radiotherapy, 6 weeks post therapy and then monthly once upto 1 year | — |
Secondary
| Measure | Time frame |
|---|---|
| The proportion of patients developing complete response, partial response and progressive disease during follow up. Timepoint: 2 years | — |
Countries
India
Contacts
Public ContactSowmiya Sampathrajan
Cancer Institute, Adyar, WIA
Outcome results
None listed