Comparing Two Drugs as Adjuvents along with the same local anaesthetic in Spinal Anesthesia for Pain Relief After Lower Abdominal Surgeries A One-Year Hospital Study.

Comparison Between Intrathecal Morphine And Dexmedetomidine With Levobupivacaine (H) For Assessment Of Post Operative Analgesic Requirement In Patients Undergoing Lower Abdominal Surgeries - A One Year Hospital Based Randomised Controlled Trial. - NIL

Status

Active, not recruiting

Phases

Phase 3Phase 4

Study type

Interventional

Source

CTRI

Registry ID

CTRI/2025/03/082649

Enrollment

140

Registered

2025-03-18

Start date

Unknown

Completion date

Unknown

Last updated

2025-04-07

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: O- Medical and Surgical

Interventions

Intervention1: Intrathecal administration of hyperbaric Levobupivacaine with two different adjuvants in lower abdominal surgeries.: Intrathecal hyperbaric Levobupivacaine with two different adjuvants,

Eligibility

Inclusion criteria

Inclusion criteria: Age - Above 18 and below or 60 years of age All genders Lower abdominal surgeries like hernia repair, hydrocoes, plastic and orthopaedic surgeries. American Society Of Anaesthesiologists (ASA) grades I and II Patients who have consented to the study.

Exclusion criteria

Exclusion criteria: Below the age of 18 and above 60 years of age. American Society Of Anaesthesiologists (ASA) grades III and IV. Patients with known co-morbidities like uncontrolled hypertension, respiratory diseases, or Angiotensin converting enzyme inhibitors, patients on alpha adrenergic receptor antagonists, patients on angiotensin receptor blockers. Patients on chronic opioid therapies. Patients who have not consented to the study.

Design outcomes

Primary

Measure	Time frame
To compare and assess the analgesic requirement for 24 hours in post operative period for patients undergoing lower abdominal surgeries under spinal anaesthesia with intrathecal morphine or dexmedetomidine with hyperbaric Levobupivacaine. Timepoint: POST OPERATIVE ANALGESIC REQUIREMENT- For first 24 hours post operatively- No. of doses of analgesics used, with rescue analgesic of choice being Inj. Tramadol 50 mg intravenously.	—

Measure

Time frame

To compare and assess the analgesic requirement for 24 hours in post operative period for patients undergoing lower abdominal surgeries under spinal anaesthesia with intrathecal morphine or dexmedetomidine with hyperbaric Levobupivacaine. Timepoint: POST OPERATIVE ANALGESIC REQUIREMENT- For first 24 hours post operatively- No. of doses of analgesics used, with rescue analgesic of choice being Inj. Tramadol 50 mg intravenously.

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Secondary

Measure	Time frame
To assess the quality, onset and regression of motor and sensory blockade of both study groups. Haemodynamic assessment in both the groups during perioperative period. To monitor and compare the side effects between both study groups, if any.Timepoint: First 30 minutes post induction- Minutes post induction PR BP 0 5 10 15 20 25 30 Next 30 minutes post induction Minutes post induction PR BP 30 45 60	—

Measure

Time frame

To assess the quality, onset and regression of motor and sensory blockade of both study groups. Haemodynamic assessment in both the groups during perioperative period. To monitor and compare the side effects between both study groups, if any.Timepoint: First 30 minutes post induction- Minutes post induction PR BP 0 5 10 15 20 25 30 Next 30 minutes post induction Minutes post induction PR BP 30 45 60

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Countries

India

Contacts

Public ContactDr Karthika K

Jawaharlal Nehru Medical College

drmontygoudar@yahoo.co.in7829164500

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026