None listed
Conditions
Interventions
Intervention1: Algal docosahexaenoic acid, DHA
: Algal docosahexaenoic acid, DHA (1 g/day, heavy metal free) packaged in 500 mg gelatin capsules. The OFA oil in a dose of 1 g/day, will be formulated
Sponsors
Bill Melinda Gates Foundation
Eligibility
Inclusion criteria
Inclusion criteria: Rural lactating women aged 20-35 years and their children within 0-4 months of age. No major morbidities Normal healthy growing child with normal delivery, no major morbidities
Exclusion criteria
Exclusion criteria: 1.Major chronic illness for mother or baby 2.Intention to leave the site 3.On any supplementation/medication 4. Moderate/severe anemia 5.Likely to change employment status
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Plasma oxidative stress markers in lactating mothers of 3-month-old babies. Plasma oxidative stress markers arylesterase activity of paraoxanase 1 (PON-1) will be assayed.Myeloperoxidase (MPO) will be measured as the rate of oxidation of o-dianisidine .Lipid peroxidase (LPO) will be measured as mmol thiobarbituric acid-reactive species formed on reaction of plasma.Total antioxidant (ToAx) will be measured using the TEAC methodTimepoint: Baseline and after 90 days of intervention | — |
Secondary
| Measure | Time frame |
|---|---|
| Hemoglobin (Hb) concentration & iron status of lactating mothers. Anthropometric growth of the children. Timepoint: Baseline & after 90 days of intervention | — |
Countries
India
Contacts
Public ContactDr Santu Ghosh
St John s Medical College, Bangalore
Outcome results
None listed