A clinical trial to study the Reduction in Microbial Load after using three different Irrigation Activation techniques to disinfect the Root Canals of teeth.

Comparative Evaluation of three different techniques on reduction in Microbial Load after endodontic treatment A Randomized Controlled Trial - nil

Status

Active, not recruiting

Phases

Phase 2

Study type

Interventional

Source

CTRI

Registry ID

CTRI/2025/03/082539

Enrollment

Registered

2025-03-18

Start date

Unknown

Completion date

Unknown

Last updated

2025-04-07

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: K045- Chronic apical periodontitis

Interventions

Intervention1: Randomised Controlled Trial: The aim of the study is to assess the reduction in microbial load after irrigation activation with XP Endo Finisher files and Er:Cr:YSGG laser for 60 second

Eligibility

Inclusion criteria

Inclusion criteria: 1. Systemically healthy patients under the age group of 18-50 years with preoperative pain 2. Teeth with single root and single canal 3. Periodontal ligament region widening or peri-apical region radiolucency with a periapical index (PAI) score of 1

Exclusion criteria

Exclusion criteria: 1. Patients with any systemic diseases 2. Presence of sinus tract or periapical abscess 3. Teeth with calcified canals, root resorption, immature/open apex, or previous root canal treatment 4. Patients who had previously taken any medication for pain

Design outcomes

Primary

Measure	Time frame
1.To evaluate the reduction in microbial load after irrigation activation with XP Endo Finisher files. 2.To evaluate the reduction in microbial load after irrigation activation with Er:Cr:YSGG laser. 3.To compare the reduction in microbial load after irrigation with XP Endo Finisher files and Er:Cr:YSGG laser. Timepoint: The no of CFU will be assessed as before and after the procedure. 24 hours.	—

Secondary

Measure	Time frame
-Reduction in painTimepoint: - 24 hours, 48 hours	—

Countries

India

Contacts

Public ContactSayali Ukey

Department of Conservative Dentistry and Endodontics

prshenoi@gmail.com9822220506

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026