Study to compare the efficacy of three different doses of Remifentanil (Opioid drug for pain relief) for decreasing the increase in heart rate and blood pressure while passing endotracheal tube

A Randomised Controlled,Prospective Study to Compare the three different doses of intravenous Remifentanil infusions to attenuate the hemodynamic response of endotracheal intubation - NIL

Status

Active, not recruiting

Phases

Phase 4

Study type

Interventional

Source

CTRI

Registry ID

CTRI/2025/03/082471

Enrollment

150

Registered

2025-03-17

Start date

Unknown

Completion date

Unknown

Last updated

2025-04-07

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: O- Medical and Surgical

Interventions

Intervention1: different intravenous infusion doses of remifentanil for attenuation of hemodynamic response: three different remifentanil intravenous infusion doses Control Intervention1: Differe

Eligibility

Inclusion criteria

Inclusion criteria: ASA grade 1 or 2 Weight 40 to 90 kgs BMI 18 to 30 No history of opioid allergy Airway assessment Modified mallampatti class 1 or 2 Thyromental distance more than 6 cms Adequate mouth opening No restriction of neck movements No retrognathia

Exclusion criteria

Exclusion criteria: ASA grade 3,4,5 Pregnant or lactating mother History of allergy to opioids Airway assessment Modified mallampatti class 3 or 4 Thyromental distance less than 6 cms Inadequate mouth opening Restriction of neck movements Presence Presence of retrognathia

Design outcomes

Primary

Measure	Time frame
compare the effect of different doses of remifentanil intravenous infusion to decrease the increase in Heart rate and blood pressure following endotracheal intubation. Post intubation values are compared with baseline values in all the three groupsTimepoint: Heart rate and Blood Pressure measurements are recorded as baseline and every minute following endotracheal intubation for first 10 minutes.	—

Secondary

Measure	Time frame
Incidence of allergy,chest wall rigidity or cough during induction & first 10 minutes after intubationTimepoint: observed for first 10 minutes following intravenous remifentanil infusion	—

Countries

India

Contacts

Public ContactDr S Thiyagarajan

SIMS Hospital

drthiyagarajan.s@simshospitals.com9790930134

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026