Health Condition 1: P368- Other bacterial sepsis of newborn
Conditions
Interventions
Intervention1: NIL: NIL
Sponsors
Bharati hospital and research centre
Eligibility
Inclusion criteria
Inclusion criteria: Inclusion criteria: Neonates admitted to the NICU who received at least one course of antibiotic therapy. Patients with documented indications for antibiotic use, including suspected or confirmed sepsis, pneumonia, NEC, or other infections. Neonates with available blood culture reports. Medical records with complete documentation of antibiotic prescriptions, including drug selection, dosing, duration, and de-escalation. Neonates who survived beyond 48 hours after antibiotic initiation and remained in the NICU to allow assessment of de-escalation practices.
Exclusion criteria
Exclusion criteria: Exclusion criteria: Patients with incomplete medical records or missing documentation of antibiotic prescriptions, culture results, or treatment modifications. Neonates who expired or were transferred before culture results became available. Cases where antibiotics were started but discontinued within 24 hours due to an alternative diagnosis or clinical improvement without confirmed infection.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| AIM: To assess compliance with antimicrobial stewardship practices in the neonatal intensive care unit (NICU). Timepoint: 1 year (jan 2024-dec 2024) | — |
Secondary
| Measure | Time frame |
|---|---|
| OBJECTIVES: 1. To determine the percentage of neonates in the NICU with negative blood cultures whose antibiotic therapy was discontinued within 48 hours of culture availability, as per retrospective documented chart records. 2. To assess the percentage of neonates in the NICU with positive blood cultures for whom antibiotic therapy was de-escalated by narrowing the spectrum within 72 hours of culture availability, as per documentation in retrospective chart records. 3. To determine the percentage of neonates in the NICU with positive blood cultures who had their antibiotic therapy changed to a different agent based on sensitivity reports, as per available documented retrospective chart records. Timepoint: 1 year (jan 2024-dec 2024) | — |
Countries
India
Contacts
Public ContactDr Nandini Malshe
bharati vidyapeeth deemed to be university pune
Outcome results
None listed