A study where we are comparing the effect of giving oxygen before surgery in lying down straight and with 30 degree head up position regarding the duration in which the oxygen saturation is normal despite the patient not breathing, in smokers and non-smokers who are undergoing emergency surgery under general anaesthesia

A comparative study of effect of preoxygenation in supine versus 30 degree head up position regarding duration of non-hypoxic apnoea in smokers and non-smokers posted for emergency surgery under general anaesthesia - NIL

Status

Active, not recruiting

Phases

Phase 1Phase 2

Study type

Interventional

Source

CTRI

Registry ID

CTRI/2025/03/082399

Enrollment

120

Registered

2025-03-17

Start date

Unknown

Completion date

Unknown

Last updated

2025-04-07

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: O- Medical and Surgical

Interventions

Intervention1: Group NST: Non-Smokers, Preoxygenation in 30 degree head up tilt from waist level: All participants had been breathing room air before the study. Group NST will receive pre oxygenation

Eligibility

Inclusion criteria

Inclusion criteria: 1. Individuals with a smoking history of 10 or more pack years, currently smoking. 2. Individuals with no history of smoking 3. Emergency surgical procedure under general anaesthesia not exceeding 90 mins

Exclusion criteria

Exclusion criteria: 1. Patients satisfying OSA criteria 2. Patients with any airway disease or known cardiopulmonary disease 3. Patients with any facial deformity 4. Patients with a previous known allergy to drugs used in the standardised anaesthetic regimen 5. Patients with anticipated difficult intubation 6. Patients who declared a phobia to facemasks or anxious patients 7. Patients in whom 1st attempt at intubation within 30s fail 8. Patients in whom EtO2 does not approach 0.90 after 5 mins of preoxygenation 9. Patients requiring oxygen therapy in the pre-operative period

Design outcomes

Primary

Measure	Time frame
To look for the non-hypoxic apnoea duration (time taken for the fall in spo2 values from baseline to 94%)Timepoint: Time in seconds to be noted from the point of discontinuing preoxygenation to the point at which spo2 value falls to 94% from baseline.	—

Secondary

Measure	Time frame
EtCO2 values before, after preoxygenation, every min. after intubation till spo2 reaches 94% and after connection of the breathing systemTimepoint: before preoxygenation, after preoxygenation every minute after intubation till spo2 drops to 94% and after connection of breathing system;HR & MAP before, after preoxygenation, every min after intubation till spo2 reaches 94% and after connection of the breathing systemTimepoint: before preoxygenation, after preoxygenation every minute after intubation till spo2 drops to 94% and after connection to breathing system;total post operative oxygen consumption in 24 hour periodTimepoint: 2 hours, 4 hours, 6 hours, 10 hours, 14 hours, 18 hours, 24 hours	—

Measure

Time frame

EtCO2 values before, after preoxygenation, every min. after intubation till spo2 reaches 94% and after connection of the breathing systemTimepoint: before preoxygenation, after preoxygenation every minute after intubation till spo2 drops to 94% and after connection of breathing system;HR & MAP before, after preoxygenation, every min after intubation till spo2 reaches 94% and after connection of the breathing systemTimepoint: before preoxygenation, after preoxygenation every minute after intubation till spo2 drops to 94% and after connection to breathing system;total post operative oxygen consumption in 24 hour periodTimepoint: 2 hours, 4 hours, 6 hours, 10 hours, 14 hours, 18 hours, 24 hours

—

Countries

India

Contacts

Public ContactJayeeta Majumdar

Midnapore Medical College and Hospital

mandiarunkr87@gmail.com8697633923

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026